Tipanat 15mg Tablet

About

Tipranavir is a non-peptidic protease inhibitor indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. It is specifically used in highly treatment-experienced adult patients who have evidence of viral replication and HIV-1 strains resistant to multiple other protease inhibitors. This medication plays a crucial role in salvage therapy regimens for patients who have failed previous antiretroviral treatments. Tipranavir works by selectively inhibiting the cleavage of Gag-Pol polyproteins, which are essential for the maturation of new infectious virions. This mechanism prevents the virus from replicating effectively, thereby reducing the viral load and improving immune function. It is typically co-administered with a low dose of ritonavir to enhance its pharmacokinetic profile, increasing its plasma concentrations and extending its half-life, ensuring optimal therapeutic levels are maintained for effective viral suppression.

Uses

• Treatment of HIV-1 infection in highly treatment-experienced adults.
• Used in patients with multi-drug resistant HIV-1 strains.
• Part of a combination antiretroviral therapy regimen.
• To reduce viral load and improve CD4+ cell counts.

Directions For Use

Take orally, usually twice daily, with food. Always co-administer with ritonavir as prescribed by your physician.

Benefits

• Effective against multi-drug resistant HIV-1.
• Reduces HIV viral load significantly.
• Improves immune system function (CD4+ counts).
• Offers a treatment option for complex HIV cases.
• Helps prevent disease progression.
• Enhances overall quality of life for patients.

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Headache
• Fatigue
• Rash
• Hepatotoxicity (liver problems)
• Hyperlipidemia (high cholesterol/triglycerides)
• Lipodystrophy (fat redistribution)
• Intracranial hemorrhage (rare)
• Pancreatitis (rare)

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate liver side effects and interact with the medication.
• Pregnancy - Use only if the potential benefit justifies the potential risk to the fetus. Consult a doctor.
• Breastfeeding - Not recommended due to potential for HIV transmission and adverse effects in the infant.
• Liver - Use with caution in patients with hepatic impairment; close monitoring of liver function is essential.
• Kidney - Generally considered safe in renal impairment, but caution is advised; no dose adjustment typically needed.
• Lung - No specific contraindications related to lung conditions, but general health should be considered.

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