About
Vinblastine is an antineoplastic (anticancer) drug that is effective as a single agent, but its therapeutic effect is enhanced when used in combination with other anticancer medications.
It is commonly used in combination therapy for Hodgkin’s disease (Stages III and IV), often with adriamycin (doxorubicin), bleomycin, and dacarbazine (ABVD regimen). Vinblastine is also used in combination with cisplatin and bleomycin for the treatment of advanced testicular carcinoma.
In addition, Vinblastine has been employed for the palliative treatment of conditions such as lymphocytic lymphoma, histiocytic lymphoma, advanced mycosis fungoides, Kaposi's sarcoma, and Histiocytosis X. It may also be used in choriocarcinoma resistant to other chemotherapy, as well as breast carcinoma unresponsive to endocrine surgery or hormonal therapy.
Vinblastine is considered one of the most effective single agents for treating Hodgkin’s disease. For previously untreated patients with advanced Hodgkin’s disease, protocols substituting cyclophosphamide for nitrogen mustard and vinblastine for vincristine in the MOPP regimen provide an alternative therapy. Patients with relapsed disease have also responded well to combination therapy that includes vinblastine.
Although advanced testicular germ-cell cancers respond to vinblastine alone, concurrent use with other anticancer agents produces superior results. The effectiveness of bleomycin is enhanced when vinblastine is administered 6–8 hours prior, as this timing allows more cancer cells to be arrested in metaphase, the phase in which bleomycin is most active.
Uses
- Cytotoxic Chemotherapy
Directions for use
This medicine will be administered by your doctor or nurse. Please do not attempt to self-administer it.
Side effects
- Alopecia (hair loss)
- Constipation
- Malaise (general weakness)
- Stomatitis (mouth sores)
- Dose-limiting bone marrow suppression: granulocytopenia, thrombocytopenia, anaemia
- Hypertension
- Central and peripheral neurotoxicity
- 8th cranial nerve damage causing vestibular and auditory toxicity
- Ischaemic cardiac toxicity
- Breathlessness
- Bone pain
- Tumour pain
- Jaw pain
- Nausea
- Vomiting
- Gastrointestinal bleeding
- Syndrome of inappropriate antidiuretic hormone (SIADH)
Safety Measures
Alcohol - Consuming alcohol while taking Vinblastin 10mg Injection is unsafe and should be avoided.
Pregnancy - Vinblastin 10mg Injection may be unsafe during pregnancy. While human data is limited, animal studies have shown potential harm to the developing baby. Your doctor will assess the benefits versus risks before prescribing this medicine. Always consult your doctor before use.
Breastfeeding - Vinblastin 10mg Injection is likely unsafe during breastfeeding, as limited human data indicates that it may pass into breast milk and potentially harm the baby.
Liver - Limited information is available on the use of Vinblastin 10mg Injection in patients with liver disease. Please consult your doctor before use.
Kidney - Vinblastin 10mg Injection should be used with caution in patients with severe kidney disease. Dose adjustments may be necessary, so consult your doctor. Regular monitoring of kidney function and other blood tests is recommended while taking this medication
Disclaimer
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