About

Voriconazole is a broad-spectrum triazole antifungal agent used to treat serious and life-threatening fungal infections. It works by inhibiting the fungal cytochrome P450-dependent 14-alpha-demethylase, an enzyme essential for ergosterol biosynthesis in the fungal cell membrane. This disruption leads to the accumulation of methylated sterols and a depletion of ergosterol, impairing fungal cell membrane integrity and function, ultimately inhibiting fungal growth and replication.

Voriconazole is effective against a wide range of fungi, including Candida species (including fluconazole-resistant strains), Aspergillus species, and other rare molds. Its intravenous formulation is particularly useful for critically ill patients or those unable to take oral medication, providing a potent option for systemic antifungal therapy.

Uses

Invasive aspergillosis
Esophageal candidiasis
Serious Candida infections (including C. krusei)
Scedosporiosis and fusariosis

Directions For Use

Administer intravenously as a slow infusion over 1-2 hours, as directed by a healthcare professional. Do not administer as a rapid bolus injection.

Benefits

Broad-spectrum antifungal activity.
Effective against resistant Candida strains.
Penetrates central nervous system.
Available in intravenous and oral forms.
Crucial for immunocompromised patients.
Improved survival in severe fungal infections.

Side Effects

Visual disturbances (blurred vision, altered color perception)
Fever
Nausea
Vomiting
Diarrhea
Headache
Rash
Elevated liver enzymes
Photosensitivity
Hallucinations
Peripheral edema
Hypokalemia

Safety Measures

Alcohol - Avoid alcohol due to potential for increased liver toxicity and interaction with voriconazole metabolism.
Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Effective contraception is required for women of childbearing potential.
Breastfeeding - Not recommended during breastfeeding due to potential for serious adverse effects in the infant.
Liver - Use with caution and reduced dosage in patients with mild to moderate hepatic impairment. Contraindicated in severe hepatic impairment.
Kidney - The intravenous formulation contains SBECD, which can accumulate in renal impairment. Oral formulation preferred or monitor closely.
Lung - Generally safe for use in patients with lung conditions, but monitor for drug-induced pneumonitis, a rare side effect.

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