Acaya 100mg Capsule

About

Itraconazole is a synthetic triazole antifungal agent renowned for its broad-spectrum activity against a wide array of fungal pathogens. Its mechanism of action involves the selective inhibition of fungal cytochrome P450-dependent enzyme 14α-demethylase. This enzyme plays a crucial role in the biosynthesis of ergosterol, an indispensable component of the fungal cell membrane. By blocking ergosterol synthesis, itraconazole disrupts the structural integrity and functional permeability of the fungal cell membrane, leading to cellular dysfunction and ultimately fungal cell death. It is highly effective against dermatophytes, yeasts, and dimorphic fungi, making it a versatile option for treating conditions such as onychomycosis, oral and esophageal candidiasis, and serious systemic mycoses like aspergillosis, blastomycosis, and histoplasmosis. Its lipophilic nature allows for good tissue penetration, contributing to its efficacy in various deep-seated infections.

Uses

• Onychomycosis (fungal nail infections)
• Oral and esophageal candidiasis
• Systemic fungal infections (e.g., aspergillosis, blastomycosis, histoplasmosis)
• Pityriasis versicolor

Directions For Use

Take capsules orally immediately after a full meal to ensure maximum absorption, or as directed by your physician.

Benefits

• Broad-spectrum antifungal activity
• Effective against dermatophytes and yeasts
• Good tissue penetration
• Oral administration convenience
• Effective for systemic mycoses
• Treats stubborn fungal infections

Side Effects

• Nausea
• Abdominal pain
• Diarrhea
• Headache
• Dizziness
• Rash
• Elevated liver enzymes
• Congestive heart failure (rare, especially with pre-existing cardiac disease)
• Peripheral neuropathy (rare)
• Hypokalemia
• Edema
• Hepatotoxicity (rare, severe)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it can increase the risk of liver toxicity and may exacerbate gastrointestinal side effects.
• Pregnancy - Contraindicated in pregnancy due to potential for teratogenicity. Effective contraception is essential for women of childbearing potential.
• Breastfeeding - Not recommended during breastfeeding as itraconazole is excreted in breast milk and could harm the infant.
• Liver - Use with caution in patients with pre-existing liver disease. Monitor liver function tests regularly, and discontinue if signs of hepatic dysfunction occur.
• Kidney - Use with caution in patients with renal impairment. Dose adjustment may be necessary, especially for long-term treatment.
• Lung - Contraindicated in patients with a history of congestive heart failure or ventricular dysfunction, as it can exacerbate these conditions.

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