Adpaxil 30mg Injection

About

Paclitaxel is a prominent taxane antineoplastic agent that functions by disrupting the dynamic equilibrium of microtubules, essential components of the cellular cytoskeleton involved in cell division and intracellular transport. It promotes the assembly of microtubules from tubulin dimers and, crucially, stabilizes them by preventing their depolymerization. This stabilization leads to an accumulation of non-functional microtubules, effectively arresting cancer cells in the G2/M phase of the cell cycle. The inability of cells to properly divide ultimately triggers programmed cell death. Administered intravenously, paclitaxel is a widely used chemotherapy for various solid tumors. Its administration requires pre-medication with corticosteroids, antihistamines, and H2 blockers to mitigate the risk of hypersensitivity reactions. Despite its side effects, including peripheral neuropathy and myelosuppression, its efficacy makes it a critical component in many cancer treatment regimens.

Uses

• Ovarian cancer
• Breast cancer
• Non-small cell lung cancer (NSCLC)
• Kaposi's sarcoma (AIDS-related)

Directions For Use

Administered intravenously, typically over 3 or 24 hours, by a healthcare professional. Pre-medication with corticosteroids, antihistamines, and H2 blockers is required to prevent hypersensitivity reactions.

Benefits

• Effective against a wide range of solid tumors.
• Can be used as first-line or subsequent therapy.
• Improves response rates and survival in various cancers.
• Often used in combination with other chemotherapies.
• Well-established efficacy profile.
• Available in different formulations (e.g., albumin-bound).

Side Effects

• Myelosuppression (neutropenia, dose-limiting)
• Peripheral neuropathy (cumulative, dose-dependent)
• Hypersensitivity reactions (can be severe)
• Alopecia (hair loss)
• Myalgia/arthralgia (muscle/joint pain)
• Nausea and vomiting (mild to moderate)
• Diarrhea
• Mucositis
• Bradycardia (slow heart rate)
• Hypotension
• Fatigue
• Injection site reactions

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased gastrointestinal irritation and liver strain.
• Pregnancy - Contraindicated. May cause fetal harm. Effective contraception is required during and after treatment.
• Breastfeeding - Not recommended. The drug can pass into breast milk and harm the infant.
• Liver - Use with caution; dosage adjustments are necessary in patients with hepatic impairment due to primary hepatic metabolism.
• Kidney - Use with caution; no specific dosage adjustments are typically required for renal impairment, but monitor closely.
• Lung - Use with caution in patients with pre-existing lung conditions; rare cases of interstitial pneumonitis have been reported.

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