About
Advastat ASP 10mg combines atorvastatin, an HMG-CoA reductase inhibitor, with aspirin, an antiplatelet agent, for comprehensive cardiovascular risk reduction. Atorvastatin 10mg effectively lowers LDL-cholesterol and reduces overall cardiovascular risk by inhibiting cholesterol synthesis and improving endothelial function. Aspirin, typically in a low dose, works by irreversibly inhibiting cyclooxygenase (COX) enzymes, thereby preventing the production of thromboxane A2, a potent platelet aggregator. This dual therapy is indicated for patients at high risk of cardiovascular events, such as those with established atherosclerotic disease, a history of myocardial infarction or stroke, or high-risk primary prevention, where both lipid management and antiplatelet therapy are warranted. The combination aims to stabilize plaques, prevent thrombotic events, and reduce the incidence of major adverse cardiovascular events. Close monitoring for bleeding risk and gastrointestinal side effects is crucial.
Uses
- Secondary prevention of cardiovascular events.
- Primary prevention in high-risk individuals.
- Management of patients with established atherosclerotic disease.
- Reduction of risk for myocardial infarction and ischemic stroke.
Directions For Use
Take one tablet orally once daily, preferably with food to minimize gastrointestinal upset, as directed by your physician.
Benefits
- Provides dual protection against heart attack and stroke.
- Lowers "bad" cholesterol and prevents blood clot formation.
- Reduces overall cardiovascular mortality and morbidity.
- Stabilizes atherosclerotic plaques and reduces inflammation.
- Offers a convenient single-pill regimen for complex conditions.
- Improves long-term cardiovascular outcomes.
Side Effects
- Gastrointestinal upset (e.g., indigestion, heartburn)
- Bleeding (e.g., bruising, nosebleeds, GI bleeding)
- Nausea
- Abdominal pain
- Headache
- Dizziness
- Elevated liver enzymes
- Rash
- Tinnitus (with higher aspirin doses)
- Fatigue
- Diarrhea
- Allergic reactions (rare)
Safety Measures
- Alcohol - Alcohol significantly increases the risk of gastrointestinal bleeding when combined with aspirin. Avoid or limit strictly.
- Pregnancy - Contraindicated in the third trimester due to potential fetal harm and bleeding risk. Use with caution in earlier trimesters.
- Breastfeeding - Aspirin is excreted in breast milk and can pose risks to the infant. Contraindicated during breastfeeding.
- Liver - Contraindicated in active liver disease. Use with caution and monitor liver function in hepatic impairment.
- Kidney - Use with caution in severe renal impairment, as aspirin can worsen kidney function and atorvastatin data is limited.
- Lung - Aspirin can exacerbate asthma in some susceptible individuals (aspirin-exacerbated respiratory disease). Use with caution.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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