About
Rosuvastatin is an HMG-CoA reductase inhibitor (statin) that reduces cholesterol synthesis in the liver, primarily lowering LDL-C and triglycerides, and increasing HDL-C. Fenofibrate is a fibric acid derivative that activates peroxisome proliferator-activated receptor alpha (PPARα), leading to reduced triglyceride levels and increased HDL-C. This combination therapy is indicated for patients with mixed dyslipidemia who require comprehensive lipid modification, particularly when elevated triglycerides and low HDL-C persist despite statin monotherapy. It works synergistically to improve the overall lipid profile, reducing the risk of cardiovascular events associated with dyslipidemia. The dual mechanism addresses multiple facets of lipid abnormalities, offering a more robust approach to managing complex lipid disorders.
Uses
- Treatment of mixed dyslipidemia.
- Reduction of elevated triglycerides.
- Increase in high-density lipoprotein (HDL) cholesterol.
- Prevention of cardiovascular events in high-risk patients.
Directions For Use
Take this medication orally, usually once daily with food, or as directed by your doctor. Do not crush or chew the tablet.
Benefits
- Comprehensive lipid profile improvement.
- Significant reduction in LDL-C and triglycerides.
- Effective increase in beneficial HDL-C.
- Reduced risk of atherosclerotic cardiovascular disease.
- Synergistic action of two lipid-modifying agents.
- Improved management of complex dyslipidemia.
Side Effects
- Muscle pain or weakness (myalgia).
- Headache.
- Nausea.
- Abdominal pain.
- Diarrhea.
- Constipation.
- Elevated liver enzymes.
- Pancreatitis (rare).
- Gallstones (rare).
- Rash.
- Fatigue.
- Dizziness.
Safety Measures
- Alcohol - Avoid excessive alcohol consumption as it can increase the risk of liver problems and muscle side effects when taking this medication.
- Pregnancy - Contraindicated during pregnancy due to potential harm to the fetus. Effective contraception is required for women of childbearing potential.
- Breastfeeding - Not recommended during breastfeeding as the active ingredients may pass into breast milk and harm the infant.
- Liver - Use with caution in patients with mild to moderate liver impairment; contraindicated in severe active liver disease. Regular liver function monitoring is essential.
- Kidney - Dose adjustment may be necessary in patients with moderate to severe kidney impairment. Contraindicated in severe renal impairment.
- Lung - Generally safe for use in patients with lung conditions, but caution is advised if unexplained respiratory symptoms develop.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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