About
Alfuzosin is an alpha-1 adrenergic antagonist primarily used in the management of benign prostatic hyperplasia (BPH). It works by selectively relaxing the smooth muscles in the prostate, bladder neck, and urethra, thereby improving urine flow and reducing bothersome lower urinary tract symptoms such as hesitancy, weak stream, incomplete emptying, and nocturia. Unlike some non-selective alpha-blockers, alfuzosin is considered uroselective, meaning it has a more targeted action on the lower urinary tract. This targeted action may contribute to a lower incidence of systemic side effects, particularly orthostatic hypotension, in some patients. Its mechanism involves blocking alpha-1 adrenergic receptors, leading to smooth muscle relaxation and improved urinary dynamics. This therapeutic effect helps alleviate the discomfort and functional limitations associated with an enlarged prostate, significantly enhancing the quality of life for affected individuals by restoring more normal urinary patterns.
Uses
- Treatment of symptoms associated with benign prostatic hyperplasia (BPH).
- Improvement of urinary flow in men with BPH.
- Reduction of urinary hesitancy and urgency.
- Alleviation of nocturia due to BPH.
Directions For Use
Take one tablet orally, usually once daily immediately after the same meal each day, or as prescribed by your doctor.
Benefits
- Relieves urinary symptoms of BPH.
- Improves urine flow rate.
- Reduces bladder outlet obstruction.
- May have a lower risk of orthostatic hypotension compared to non-uroselective alpha-blockers.
- Enhances quality of life for BPH patients.
- Convenient once-daily dosing.
Side Effects
- Dizziness
- Headache
- Fatigue
- Nausea
- Abdominal pain
- Orthostatic hypotension (dizziness upon standing)
- Rhinitis (stuffy nose)
- Diarrhea
- Ejaculation disorders
- Palpitations
- Syncope (fainting)
- Priapism (rare)
Safety Measures
- Alcohol - Alcohol can increase the risk of dizziness and orthostatic hypotension when taken with alfuzosin. Avoid or limit alcohol consumption.
- Pregnancy - Alfuzosin is not indicated for use in women.
- Breastfeeding - Alfuzosin is not indicated for use in women.
- Liver - Use with caution in patients with mild to moderate hepatic impairment; contraindicated in severe hepatic impairment.
- Kidney - Generally safe in patients with renal impairment, but caution is advised in severe cases. No dose adjustment typically needed for mild to moderate impairment.
- Lung - No specific contraindications or precautions related to lung conditions are generally noted for alfuzosin.
Disclaimer
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