Alphalan 2mg Tablet

About

Alphalan 2mg Tablet is an oral alkylating agent, a class of chemotherapy drugs that exert their therapeutic effect by damaging the DNA of cancer cells. It forms covalent bonds with DNA, leading to cross-linking and disruption of DNA replication and transcription. This action is cytotoxic to rapidly dividing cells, making it effective in controlling the growth and spread of various malignancies.

This low-dose oral formulation is typically used for maintenance therapy or in less aggressive treatment regimens for conditions like multiple myeloma and certain ovarian cancers. Its oral route offers convenience for long-term outpatient management. Regular monitoring of hematological parameters is crucial to detect and manage myelosuppression, a common and dose-limiting side effect.

Uses

• Maintenance therapy for multiple myeloma.
• Treatment of advanced ovarian cancer.
• Palliative care for breast cancer.
• Management of certain types of leukemia.

Directions For Use

Take orally on an empty stomach, usually once daily or as directed by your physician. Swallow the tablet whole with water.

Benefits

• Convenient oral administration for long-term use.
• Effective in controlling disease progression.
• Can be used as part of combination therapy.
• Helps maintain remission in certain cancers.
• Well-tolerated at lower doses compared to high-dose regimens.
• Established role in specific oncology protocols.

Side Effects

• Bone marrow suppression (leukopenia, thrombocytopenia, anemia)
• Nausea and vomiting
• Diarrhea
• Oral mucositis
• Alopecia (hair thinning or loss)
• Skin rash
• Secondary malignancies (long-term risk)
• Infertility
• Hepatotoxicity (rare)
• Pulmonary fibrosis (very rare)
• Amenorrhea
• Azoospermia

Safety Measures

• Alcohol - Avoid or limit alcohol intake as it may worsen gastrointestinal side effects and potentially increase liver strain.
• Pregnancy - Contraindicated in pregnancy due to significant risk of fetal harm. Effective contraception is essential for both partners.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and pose a risk to the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Use with caution in patients with renal impairment; dose reduction is often required due to altered drug clearance.
• Lung - Monitor for rare signs of pulmonary toxicity, such as interstitial pneumonitis, especially with prolonged use.

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