Alphalan 50mg Injection

About

Alphalan 50mg Injection is a potent alkylating chemotherapeutic agent, designed to exert its cytotoxic effects by cross-linking DNA strands within cancer cells. This action disrupts DNA replication and transcription, ultimately leading to cell cycle arrest and programmed cell death. Its mechanism is cell-cycle non-specific, making it effective against a broad range of rapidly dividing cells.

Administered intravenously, often in high-dose regimens, Alphalan is a critical component in the treatment of multiple myeloma, particularly in preparation for autologous stem cell transplantation. It is also used for regional perfusion in certain localized cancers. Due to its significant myelosuppressive potential, close hematological monitoring is essential during and after administration.

Uses

• High-dose conditioning for stem cell transplantation in multiple myeloma.
• Treatment of advanced ovarian cancer.
• Regional arterial perfusion for melanoma.
• Palliative treatment of breast cancer.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion rate are carefully calculated based on body surface area and treatment protocol.

Benefits

• Crucial for high-dose chemotherapy regimens.
• Effective in achieving disease remission in multiple myeloma.
• Can be used for regional treatment of localized cancers.
• Potent cytotoxic action against cancer cells.
• Well-established role in oncology protocols.
• Contributes to improved survival outcomes in specific settings.

Side Effects

• Severe bone marrow suppression (pancytopenia)
• Nausea and vomiting (often severe)
• Oral mucositis and stomatitis
• Diarrhea
• Alopecia (hair loss)
• Skin rash
• Hepatotoxicity (liver damage)
• Pulmonary fibrosis (rare but serious)
• Secondary malignancies (long-term risk)
• Infertility (amenorrhea, azoospermia)
• Hypersensitivity reactions
• Venous occlusive disease of the liver (with high doses)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may worsen gastrointestinal side effects and potentially increase liver toxicity.
• Pregnancy - Absolutely contraindicated in pregnancy due to severe teratogenic and embryotoxic effects. Strict contraception is required.
• Breastfeeding - Breastfeeding is contraindicated due to the high likelihood of drug excretion into breast milk and potential harm to the infant.
• Liver - Use with extreme caution in patients with pre-existing hepatic impairment; dose adjustments are critical, and liver function must be closely monitored.
• Kidney - Use with caution in patients with renal impairment; significant dose reduction is often necessary due to reduced drug clearance.
• Lung - Monitor closely for signs of pulmonary toxicity, such as interstitial pneumonitis or fibrosis, especially with high-dose regimens.

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