Alphalan 5mg Tablet

About

Alphalan 5mg Tablet is an alkylating agent, a type of chemotherapy drug that works by interfering with the DNA of cancer cells. It forms cross-links in DNA strands, preventing them from replicating and leading to cell death. This mechanism is non-specific to the cell cycle, meaning it can affect cells at various stages of division, making it effective against rapidly proliferating cancer cells.

Administered orally, Alphalan is primarily used in the treatment of multiple myeloma and certain ovarian cancers. Its cytotoxic action helps to reduce tumor burden and control disease progression. Due to its potent nature, careful monitoring of blood counts and other potential side effects is crucial throughout the treatment period to manage toxicity.

Uses

• Treatment of multiple myeloma.
• Management of advanced ovarian cancer.
• Palliative treatment of breast cancer.
• Used in high-dose regimens for stem cell transplantation.

Directions For Use

Take orally on an empty stomach, usually once daily or as directed by your doctor. Swallow the tablet whole with water.

Benefits

• Established efficacy in multiple myeloma.
• Oral formulation offers convenience for patients.
• Can be used in combination with other therapies.
• Effective in reducing tumor burden.
• A cornerstone in certain high-dose chemotherapy regimens.
• Contributes to disease control and improved outcomes.

Side Effects

• Bone marrow suppression (severe myelosuppression)
• Nausea and vomiting
• Diarrhea
• Oral mucositis (mouth sores)
• Alopecia (hair loss)
• Skin rash
• Pulmonary fibrosis (rare)
• Secondary malignancies (long-term risk)
• Amenorrhea (absence of menstruation)
• Azoospermia (absence of sperm)
• Hepatotoxicity (liver damage)
• Hypersensitivity reactions

Safety Measures

• Alcohol - Avoid alcohol as it may exacerbate gastrointestinal side effects and potentially increase liver strain.
• Pregnancy - Contraindicated in pregnancy due to severe teratogenic effects. Effective contraception is mandatory for both male and female patients.
• Breastfeeding - Not recommended during breastfeeding as the drug is likely excreted in breast milk and can harm the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary, and liver function should be monitored.
• Kidney - Use with caution in patients with renal impairment; dose reduction is often required due to altered drug clearance.
• Lung - Monitor for signs of pulmonary toxicity, such as pulmonary fibrosis, which is a rare but serious adverse effect.

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