About

Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a broad range of indications, including the treatment of major depressive disorder, generalized anxiety disorder, diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Its therapeutic action stems from increasing the levels of serotonin and norepinephrine in the central nervous system, neurotransmitters that are critically involved in mood regulation, pain perception, and emotional processing. By modulating these key neurochemical pathways, duloxetine effectively helps to alleviate the core symptoms of depression and anxiety, while also significantly reducing various types of chronic pain. This multifaceted pharmacological profile makes it a valuable and versatile treatment option for patients who present with co-occurring mood and chronic pain disorders, offering comprehensive symptom management.

Uses

Treatment of major depressive disorder.
Management of generalized anxiety disorder.
Relief of diabetic peripheral neuropathic pain.
Treatment of fibromyalgia.

Directions For Use

Take orally once or twice daily, with or without food. Swallow the capsule whole; do not crush, chew, or open.

Benefits

Effectively treats depression and anxiety.
Reduces chronic neuropathic pain.
Alleviates fibromyalgia symptoms.
Improves mood and overall well-being.
Offers a broad spectrum of therapeutic uses.
Helps manage co-occurring pain and mood disorders.

Side Effects

Nausea
Dry mouth
Constipation
Dizziness
Fatigue
Insomnia
Sweating
Headache
Sexual dysfunction
Increased blood pressure
Liver enzyme elevation (rare)
Serotonin syndrome (rare)

Safety Measures

Alcohol - Avoid excessive alcohol consumption due to increased risk of liver damage and central nervous system depression.
Pregnancy - Use during pregnancy is generally not recommended, especially in the third trimester, due to potential risks to the newborn; discuss with a doctor.
Breastfeeding - Excreted in human milk; not recommended during breastfeeding as potential effects on the infant are unknown.
Liver - Contraindicated in patients with chronic liver disease or cirrhosis due to increased risk of liver injury.
Kidney - Not recommended for patients with severe renal impairment (eGFR <30 mL/min/1.73m²) due to increased drug exposure.
Lung - No specific contraindications or dose adjustments related to lung conditions are typically required.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.

Shipping & Location