About
Aripiprazole is an atypical antipsychotic medication characterized by its unique mechanism of action as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and an antagonist at serotonin 5-HT2A receptors. This distinct pharmacological profile allows it to stabilize dopamine and serotonin systems in the brain, which is crucial for its therapeutic effects. It is widely utilized in the management of various psychiatric conditions, including schizophrenia, where it helps to alleviate psychotic symptoms. It is also effective in treating manic and mixed episodes associated with bipolar I disorder, and serves as an adjunctive treatment for major depressive disorder when antidepressants alone are insufficient. Furthermore, aripiprazole is approved for managing irritability associated with autistic disorder. The sustained-release (SR) formulation provides the benefit of once-daily dosing, enhancing patient adherence and maintaining consistent therapeutic levels throughout the day, thereby optimizing symptom control.
Uses
- Treatment of schizophrenia
- Acute treatment of manic and mixed episodes in bipolar I disorder
- Adjunctive treatment for major depressive disorder
- Treatment of irritability associated with autistic disorder
Directions For Use
Take this sustained-release tablet whole, do not crush, chew, or break it. It can be taken with or without food, as directed by your doctor.
Benefits
- Manages psychotic symptoms effectively
- Stabilizes mood in bipolar disorder
- Reduces depressive symptoms when used adjunctively
- Once-daily dosing for sustained-release formulation
- Lower risk of weight gain compared to some other antipsychotics
- Improves irritability in autistic disorder
Side Effects
- Nausea and vomiting
- Constipation
- Headache
- Dizziness
- Insomnia
- Akathisia (restlessness)
- Anxiety
- Restlessness
- Tremor
- Blurred vision
- Weight gain (less common than other antipsychotics)
- Orthostatic hypotension
Safety Measures
- Alcohol - Avoid alcohol consumption as it can increase CNS depression, dizziness, and drowsiness associated with aripiprazole.
- Pregnancy - Use only if the potential benefits outweigh the risks. Monitor neonates for withdrawal symptoms (e.g., tremor, agitation) if exposed during the third trimester.
- Breastfeeding - Aripiprazole is excreted into breast milk. Not recommended due to potential for adverse effects in the infant; consult your doctor.
- Liver - Use with caution in patients with liver impairment. Metabolism may be reduced, increasing drug levels and side effect risk. Dose adjustment may be necessary.
- Kidney - Use with caution in patients with kidney impairment. Excretion may be affected, leading to drug accumulation. Dose adjustment may be necessary.
- Lung - Use with caution in patients with severe respiratory conditions. Aripiprazole can cause respiratory depression, especially when combined with other CNS depressants.
Disclaimer
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