About
Benidipine is a third-generation dihydropyridine calcium channel blocker that exerts its therapeutic effects by inhibiting the influx of calcium ions into vascular smooth muscle cells and cardiac muscle cells. This dual action on both L-type and T-type calcium channels leads to potent peripheral and coronary vasodilation, effectively reducing systemic vascular resistance and lowering blood pressure. Its prolonged duration of action allows for convenient once-daily dosing, ensuring sustained antihypertensive and antianginal effects. By improving coronary blood flow and reducing cardiac workload, benidipine is highly effective in managing essential hypertension and relieving symptoms of angina pectoris. It is particularly noted for its favorable safety profile and potential renoprotective properties, making it a valuable option in cardiovascular therapy. This medication helps to relax blood vessels, allowing blood to flow more easily.
Uses
- Treatment of essential hypertension.
- Management of angina pectoris.
- Used alone or in combination with other antihypertensive agents.
- May be beneficial in patients with concomitant renal impairment.
Directions For Use
Take orally once daily, preferably after breakfast, as directed by your doctor. Do not crush or chew the tablet.
Benefits
- Effective blood pressure reduction.
- Relieves symptoms of angina.
- Long-acting, once-daily dosing.
- Good tolerability profile.
- May have renoprotective effects.
- Reduces cardiovascular workload.
Side Effects
- Headache
- Dizziness
- Flushing
- Palpitations
- Edema (swelling of ankles/feet)
- Nausea
- Fatigue
- Gingival hyperplasia (rare)
- Rash
- Hypotension (excessive)
- Bradycardia (rare)
- Gastrointestinal discomfort
Safety Measures
- Alcohol - Alcohol may enhance the hypotensive effect of benidipine; use with caution.
- Pregnancy - Use during pregnancy is generally not recommended unless clearly necessary, as safety has not been established.
- Breastfeeding - Avoid during breastfeeding as it may be excreted in breast milk and potential effects on the infant are unknown.
- Liver - Use with caution in patients with hepatic impairment; dose adjustment may be required in severe cases.
- Kidney - Generally safe and may be beneficial in renal impairment; no dose adjustment typically needed for mild-moderate.
- Lung - No specific contraindications or dose adjustments related to lung conditions.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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