About
Cabolong is a small molecule tyrosine kinase inhibitor that targets multiple receptor tyrosine kinases (RTKs) crucial for tumor growth, angiogenesis, and metastasis. Key targets include MET, VEGFR1, VEGFR2, VEGFR3, AXL, RET, ROS1, TYRO3, and KIT. By inhibiting these pathways, the medication effectively suppresses tumor proliferation, reduces vascularization, and promotes apoptosis in various cancer types. Its broad spectrum of activity makes it a valuable treatment option for advanced malignancies that may have developed resistance to other therapies.
The drug works by interfering with the complex signaling cascades that drive cancer progression, thereby slowing disease advancement and potentially improving patient outcomes. It is typically administered orally and requires careful monitoring due to its potent systemic effects and potential for significant adverse reactions. This targeted approach helps to manage disease progression in specific oncology indications.
Uses
- Treatment of advanced renal cell carcinoma (RCC).
- Management of hepatocellular carcinoma (HCC) in patients previously treated with sorafenib.
- Therapy for differentiated thyroid cancer (DTC) that is refractory to radioactive iodine.
- Investigation in other solid tumors with specific molecular targets.
Directions For Use
Take orally as directed by your physician, usually once daily, with or without food. Do not crush or chew the tablet.
Benefits
- Targets multiple pathways involved in cancer growth.
- Effective in various advanced solid tumors.
- Can slow disease progression.
- May improve overall survival in specific indications.
- Oral administration offers convenience.
- Useful in patients resistant to prior therapies.
Side Effects
- Diarrhea
- Fatigue
- Nausea
- Vomiting
- Decreased appetite
- Hand-foot syndrome
- Hypertension
- Abdominal pain
- Weight loss
- Stomatitis
- Dysphonia
- Hypothyroidism
Safety Measures
- Alcohol - Avoid or limit alcohol consumption as it may exacerbate gastrointestinal side effects or interact with the medication's metabolism.
- Pregnancy - Contraindicated in pregnancy due0 to potential fetal harm. Effective contraception must be used during treatment and for a period after.
- Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and harm the infant. Discontinue breastfeeding or the medication.
- Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Monitor liver function closely.
- Kidney - Use with caution in patients with severe renal impairment. Dose adjustments may be required based on kidney function.
- Lung - Monitor for new or worsening pulmonary symptoms, including pneumonitis or interstitial lung disease, though less common.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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