Cabotib 60mg Tablet

About

Cabotib 60mg Tablet contains Cabozantinib, a multi-targeted receptor tyrosine kinase (RTK) inhibitor. It works by inhibiting the activity of several RTKs, including MET, VEGFR2, AXL, and RET, which are involved in tumor growth, angiogenesis, and metastasis. By blocking these pathways, Cabozantinib helps to reduce tumor size, inhibit the formation of new blood vessels that feed tumors, and prevent the spread of cancer cells. This targeted action makes it an effective treatment for various advanced cancers.

The drug is designed to interfere with the signaling pathways that drive cancer progression, offering a therapeutic option for patients with specific types of malignancies. Its broad spectrum of RTK inhibition contributes to its efficacy in complex tumor microenvironments, addressing multiple mechanisms of resistance and disease progression.

Uses

• Advanced Renal Cell Carcinoma
• Hepatocellular Carcinoma
• Medullary Thyroid Cancer
• Other advanced solid tumors

Directions For Use

Take orally once daily with or without food. Swallow the tablet whole; do not crush or chew.

Benefits

• Inhibits multiple oncogenic pathways
• Reduces tumor size and progression
• Prolongs progression-free survival
• Improves overall survival in certain cancers
• Targets angiogenesis to starve tumors
• Effective in some resistant cancer types

Side Effects

• Fatigue
• Diarrhea
• Nausea
• Vomiting
• Decreased appetite
• Hypertension
• Palmar-plantar erythrodysesthesia
• Weight loss
• Abdominal pain
• Stomatitis
• Proteinuria
• Dysphonia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may exacerbate certain side effects or increase liver strain.
• Pregnancy - Contraindicated during pregnancy as it can cause fetal harm. Women of childbearing potential must use effective contraception.
• Breastfeeding - Not recommended during breastfeeding as the drug may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary for moderate to severe hepatic dysfunction.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be required.
• Lung - Monitor for pulmonary embolism or interstitial lung disease; use with caution in patients with pre-existing lung conditions.

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