Cabozat 40mg Tablet

About

Cabozantinib is a potent, multi-targeted receptor tyrosine kinase (RTK) inhibitor that has demonstrated significant efficacy in treating various advanced cancers, including medullary thyroid cancer (MTC), renal cell carcinoma (RCC), and hepatocellular carcinoma (HCC). Its broad inhibitory profile targets multiple RTKs crucial for tumor growth, angiogenesis, and metastasis. Key targets include MET, VEGFR1, 2, and 3, AXL, and RET. By simultaneously blocking these diverse pathways, cabozantinib effectively disrupts the complex signaling networks that drive cancer progression.

This comprehensive inhibition leads to suppressed tumor proliferation, reduced blood vessel formation within tumors, and inhibition of metastatic spread. Clinically, cabozantinib has shown to significantly prolong progression-free survival and overall survival in patients with advanced malignancies who often have limited treatment options. Its ability to address multiple oncogenic drivers makes it a valuable therapeutic option in challenging cancer settings, improving outcomes for patients with aggressive diseases.

Uses

• Medullary Thyroid Cancer (MTC)
• Renal Cell Carcinoma (RCC)
• Hepatocellular Carcinoma (HCC)
• Differentiated Thyroid Cancer (DTC)

Directions For Use

Take orally once daily on an empty stomach (at least 2 hours after and 1 hour before food).

Benefits

• Multi-targeted action against various RTKs
• Effective in multiple advanced cancers
• Can prolong progression-free survival
• Oral administration for patient convenience
• Reduces tumor growth and metastasis
• Approved for difficult-to-treat cancers

Side Effects

• Diarrhea
• Palmar-plantar erythrodysesthesia (hand-foot syndrome)
• Fatigue
• Nausea and vomiting
• Hypertension (high blood pressure)
• Decreased appetite
• Weight loss
• Stomatitis (mouth sores)
• Dysphonia (hoarseness)
• Proteinuria
• Hypothyroidism
• Hair discoloration

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of liver toxicity and gastrointestinal side effects.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Use effective contraception during and for at least 4 months after treatment.
• Breastfeeding - Not recommended during breastfeeding as the drug can pass into breast milk and harm the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests closely and adjust dose as needed.
• Kidney - Use with caution in patients with severe renal impairment; dosage adjustments may be necessary.
• Lung - Monitor for potential pulmonary adverse events, including pneumonitis, though rare.

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