Cadsonib 200mg Tablet 30's

About

Cabozantinib is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that targets MET, VEGFR1, 2, and 3, AXL, RET, ROS1, TYRO3, MER, and KIT. These receptors are involved in both normal cellular function and pathological processes such as tumor angiogenesis, invasiveness, metastasis, and drug resistance. By inhibiting these kinases, cabozantinib helps to block the growth and spread of cancer cells and reduce blood supply to tumors. Its broad spectrum of targets makes it effective in complex tumor microenvironments and in cancers that have developed resistance to other therapies.

It is approved for the treatment of various advanced cancers, including medullary thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma. Close monitoring for adverse effects, particularly hypertension and gastrointestinal events, is crucial during treatment to ensure patient safety and optimize therapeutic outcomes.

Uses

• Advanced renal cell carcinoma (RCC)
• Hepatocellular carcinoma (HCC) in patients previously treated with sorafenib
• Progressive, metastatic medullary thyroid cancer (MTC)
• Differentiated thyroid cancer (DTC) refractory to radioactive iodine

Directions For Use

Take orally once daily on an empty stomach (at least 2 hours after and 1 hour before food). Swallow tablets whole.

Benefits

• Effective against multiple advanced cancers.
• Targets various pathways involved in cancer growth.
• Can improve progression-free survival.
• Oral administration for patient convenience.
• Approved for specific difficult-to-treat cancers.
• Offers a treatment option for refractory cases.

Side Effects

• Diarrhea
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Fatigue
• Nausea and vomiting
• Decreased appetite
• Hypertension (high blood pressure)
• Weight loss
• Stomatitis (mouth sores)
• Abdominal pain
• Dysphonia (hoarseness)
• Hypothyroidism
• Proteinuria

Safety Measures

• Alcohol - Avoid or limit alcohol, as it may exacerbate gastrointestinal side effects or liver toxicity.
• Pregnancy - Not recommended during pregnancy due to potential harm to the fetus. Use effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after due to potential harm to the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustment may be necessary.
• Kidney - Use with caution in patients with kidney impairment; dose adjustment may be necessary.
• Lung - Rare but serious pulmonary events, including pneumonitis, have been reported; monitor for respiratory symptoms.

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