Canmab 440mg Injection

About

Trastuzumab is a recombinant DNA-derived humanized monoclonal antibody that selectively binds with high affinity to the extracellular domain of the human epidermal growth factor receptor 2 (HER2) protein. Overexpression of HER2 is observed in a subset of breast and gastric cancers and is associated with aggressive disease. Trastuzumab works by inhibiting the proliferation of human tumor cells that overexpress HER2.

This targeted therapy helps to block the growth signals that drive cancer cell division and survival, leading to tumor regression or stabilization. It is often used in combination with chemotherapy or as a single agent, depending on the specific cancer type and stage, and requires HER2 testing to confirm suitability for treatment.

Uses

• HER2-positive metastatic breast cancer
• Adjuvant treatment of HER2-positive early breast cancer
• HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma
• Neoadjuvant treatment of HER2-positive early breast cancer

Directions For Use

Administered intravenously by a healthcare professional. Dosage and infusion rate are determined by body weight and specific treatment protocol.

Benefits

• Targets HER2-positive cancer cells specifically.
• Improves survival rates in HER2-positive breast cancer.
• Effective in metastatic and early-stage disease.
• Can be combined with chemotherapy.
• Reduces risk of cancer recurrence.
• Offers a personalized treatment approach.

Side Effects

• Infusion-related reactions (fever, chills)
• Cardiotoxicity (heart problems, e.g., decreased ejection fraction)
• Diarrhea
• Nausea
• Fatigue
• Headache
• Rash
• Myelosuppression (rare)
• Cough
• Dyspnea (shortness of breath)
• Muscle pain
• Peripheral edema

Safety Measures

• Alcohol - No specific interaction, but general health advice to limit alcohol during cancer treatment applies.
• Pregnancy - Not recommended during pregnancy due to potential harm to the fetus. Use effective contraception.
• Breastfeeding - Breastfeeding is not recommended during treatment and for a period after due to potential harm to the infant.
• Liver - Use with caution; no specific dose adjustment guidelines, but monitor liver function.
• Kidney - Use with caution; no specific dose adjustment guidelines, but monitor kidney function.
• Lung - Use with caution; rare cases of interstitial pneumonitis and pulmonary fibrosis have been reported.

Disclaimer

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