Carbenz 150mg Injection

About

Carboplatin is a platinum-based antineoplastic agent widely used in chemotherapy. It functions by forming DNA adducts, which interfere with DNA replication and transcription, ultimately leading to programmed cell death in rapidly dividing cancer cells. Its mechanism of action is similar to that of alkylating agents, causing inter-strand and intra-strand crosslinks in DNA. This disruption of genetic material makes it effective against a variety of solid tumors.

Administered intravenously, carboplatin is often preferred over cisplatin due to its generally milder nephrotoxicity and neurotoxicity, although it causes more pronounced myelosuppression. Its efficacy and relatively manageable side effect profile make it a cornerstone in many cancer treatment regimens, either as a single agent or in combination with other chemotherapeutic drugs.

Uses

• Treatment of advanced ovarian carcinoma.
• Management of small cell lung cancer.
• Used in certain types of head and neck cancers.
• Part of regimens for germ cell tumors.

Directions For Use

This medication is administered intravenously by a qualified healthcare professional. The dosage is carefully calculated based on the patient's body surface area and renal function.

Benefits

• Effective against a broad spectrum of solid tumors.
• Often used in combination therapy to enhance efficacy.
• Generally less nephrotoxic than cisplatin.
• Manageable side effect profile compared to some other platinum agents.
• Can be used in patients with compromised renal function (with dose adjustment).
• Plays a crucial role in adjuvant and palliative cancer care.

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Peripheral neuropathy
• Ototoxicity (hearing problems)
• Hypersensitivity reactions
• Alopecia (hair loss)
• Fatigue and weakness
• Electrolyte disturbances
• Elevated liver enzymes
• Kidney dysfunction
• Mucositis (inflammation of mucous membranes)
• Diarrhea or constipation

Safety Measures

• Alcohol - Avoid or limit alcohol consumption due to potential for increased liver toxicity and exacerbation of gastrointestinal side effects.
• Pregnancy - Carboplatin is contraindicated during pregnancy due to severe teratogenic effects. Effective contraception is essential for both male and female patients during and for a period after treatment.
• Breastfeeding - Breastfeeding is not recommended during carboplatin treatment as the drug can pass into breast milk and potentially harm the infant.
• Liver - Use with caution in patients with pre-existing liver conditions. Liver function tests should be monitored closely, and dose adjustments may be necessary in severe impairment.
• Kidney - Dose adjustment is crucial based on creatinine clearance to prevent severe myelosuppression and nephrotoxicity. Regular monitoring of renal function is required throughout treatment.
• Lung - Use with caution in patients with pre-existing lung conditions. While rare, pulmonary toxicity, including interstitial pneumonitis, has been reported.

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