Carbokast 150mg Injection

About

Carbokast 150mg Injection, likely containing carboplatin, is a platinum-based alkylating agent widely used in the treatment of various solid tumors, particularly ovarian, lung, and head and neck cancers. It functions by forming inter- and intra-strand DNA cross-links, which inhibit DNA replication and transcription, ultimately leading to cell cycle arrest and apoptosis. Carboplatin is a second-generation platinum compound, designed to have a more favorable toxicity profile, especially less nephrotoxicity and neurotoxicity, compared to its predecessor, cisplatin.

Administered intravenously, Carbokast exerts its cytotoxic effects by damaging the genetic material of cancer cells, preventing their growth and division. Its efficacy is often observed in combination chemotherapy regimens, where it plays a crucial role in enhancing therapeutic outcomes. Due to its myelosuppressive effects, particularly thrombocytopenia, careful monitoring of blood counts is essential throughout treatment. Its systemic action requires vigilant management of potential toxicities to optimize patient safety and treatment efficacy.

Uses

• Ovarian cancer
• Non-small cell lung cancer
• Small cell lung cancer
• Head and neck cancer

Directions For Use

This medication is administered intravenously by a healthcare professional. Do not self-administer.

Benefits

• Effective against a broad range of solid tumors.
• Often used in combination with other chemotherapies.
• Generally better tolerated than cisplatin regarding nephrotoxicity and neurotoxicity.
• Can induce tumor regression and improve survival.
• Offers a standard treatment option for many cancers.
• Well-established efficacy in oncology protocols.

Side Effects

• Myelosuppression (thrombocytopenia, leukopenia, anemia)
• Nausea and vomiting (less severe than cisplatin)
• Fatigue
• Peripheral neuropathy (less common than cisplatin)
• Ototoxicity (hearing loss, rare)
• Allergic reactions (hypersensitivity)
• Elevated liver enzymes
• Electrolyte disturbances (hypomagnesemia, hypokalemia)
• Alopecia (hair thinning)
• Mucositis
• Diarrhea
• Nephrotoxicity (rare, mild)

Safety Measures

• Alcohol - Avoid alcohol as it may exacerbate gastrointestinal side effects or potentially increase liver toxicity.
• Pregnancy - Carbokast is teratogenic and embryotoxic; it is contraindicated in pregnancy. Women of childbearing potential must use effective contraception.
• Breastfeeding - Breastfeeding is contraindicated due to the potential for serious adverse effects on the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function closely as hepatotoxicity can occur.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary, and kidney function should be monitored, although nephrotoxicity is less common than with cisplatin.
• Lung - Monitor for signs of pulmonary toxicity, such as interstitial lung disease, which is a rare but serious adverse effect.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.