CARCA 25 15

About

Carvedilol is a non-selective beta-adrenergic blocker with concomitant alpha-1 blocking activity, making it a unique agent in the management of various cardiovascular conditions. Its dual mechanism of action contributes to its therapeutic efficacy: beta-blockade reduces heart rate and myocardial contractility, while alpha-1 blockade induces vasodilation, leading to a reduction in peripheral vascular resistance. This combined effect results in a decrease in blood pressure and improved cardiac output.

It is primarily indicated for the treatment of chronic stable heart failure, hypertension, and left ventricular dysfunction following a myocardial infarction. By mitigating the effects of stress hormones on the heart and blood vessels, carvedilol helps to alleviate symptoms, prevent disease progression, and significantly improve patient outcomes and survival rates in these critical conditions.

Uses

• Chronic heart failure
• Hypertension (high blood pressure)
• Left ventricular dysfunction after myocardial infarction
• Angina pectoris

Directions For Use

Take this medication orally as directed by your doctor, usually once or twice daily with food. Do not crush or chew the tablet.

Benefits

• Lowers high blood pressure effectively.
• Improves heart function in heart failure.
• Reduces risk of cardiovascular events.
• Decreases heart rate and workload.
• Provides alpha-1 blockade for vasodilation.
• Enhances survival in certain cardiac conditions.

Side Effects

• Dizziness
• Fatigue
• Low blood pressure (hypotension)
• Bradycardia (slow heart rate)
• Nausea
• Diarrhea
• Headache
• Shortness of breath
• Weight gain
• Edema (swelling)
• Cold extremities
• Impotence

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it can increase the hypotensive effects of carvedilol and worsen dizziness.
• Pregnancy - Generally not recommended during pregnancy unless clearly necessary, as it may cause fetal harm. Consult your doctor.
• Breastfeeding - Carvedilol may pass into breast milk. Use with caution and only if the potential benefit outweighs the risk to the infant.
• Liver - Use with extreme caution in patients with severe liver impairment, as carvedilol is extensively metabolized by the liver.
• Kidney - Generally safe for use in patients with kidney conditions, but dose adjustments may be needed in severe renal impairment.
• Lung - Use with caution in patients with bronchospastic disease (e.g., asthma) due to its non-selective beta-blocking activity.

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