CEFOGIVE-S 1.5GM 1

About

CEFOGIVE-S 1.5GM is an injectable antibiotic combination comprising Cefoperazone, a third-generation cephalosporin, and Sulbactam, a potent beta-lactamase inhibitor. Cefoperazone exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to bacterial cell lysis. It possesses broad-spectrum activity against a wide range of Gram-positive and Gram-negative bacteria. Sulbactam acts as a suicide inhibitor, irreversibly binding to and inactivating a broad spectrum of bacterial beta-lactamase enzymes, which are frequently responsible for conferring resistance to beta-lactam antibiotics. By protecting Cefoperazone from enzymatic degradation, Sulbactam significantly extends its antibacterial spectrum, making the combination highly effective against beta-lactamase-producing organisms. This synergistic action makes CEFOGIVE-S a valuable agent for treating severe and complicated infections, including intra-abdominal infections, pelvic inflammatory disease, and respiratory tract infections, particularly when resistant pathogens are suspected.

Uses

• Intra-abdominal infections
• Pelvic inflammatory disease
• Skin and soft tissue infections
• Respiratory tract infections (e.g., pneumonia)

Directions For Use

This medication is administered intravenously or intramuscularly by a healthcare professional. The dosage and duration of treatment will be determined by your doctor.

Benefits

• Broad-spectrum antibacterial activity
• Effective against beta-lactamase producing bacteria
• Potent against many resistant Gram-negative pathogens
• Good penetration into various body fluids and tissues
• Suitable for severe and complicated infections
• Improved clinical outcomes in resistant infections

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Injection site pain
• Rash
• Fever
• Elevated liver enzymes
• Eosinophilia
• Thrombocytopenia
• Allergic reactions (e.g., anaphylaxis)
• Pseudomembranous colitis
• Hypoprothrombinemia (due to Cefoperazone)

Safety Measures

• Alcohol - Cefoperazone can cause a disulfiram-like reaction (flushing, headache, nausea, vomiting) when consumed with alcohol. Avoid alcohol during and for several days after treatment.
• Pregnancy - Use during pregnancy only if clearly needed and the potential benefits outweigh the risks. Consult a doctor.
• Breastfeeding - Small amounts may pass into breast milk. Use with caution; monitor the infant for adverse effects like diarrhea or rash.
• Liver - Use with caution in patients with pre-existing liver conditions. Dose adjustment may be necessary in severe hepatic impairment.
• Kidney - Dose adjustment is typically required in patients with impaired renal function to prevent accumulation and potential toxicity.
• Lung - Generally safe for use in patients with lung conditions, unless there are specific contraindications related to severe allergic reactions.

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