KABICEFTAM 1.5GM

About

Kabiceftam is a potent injectable antibiotic combining Cefoperazone, a third-generation cephalosporin, with Sulbactam, a beta-lactamase inhibitor. Cefoperazone exerts its bactericidal effect by interfering with bacterial cell wall synthesis, leading to cell lysis and death. However, many bacteria produce beta-lactamase enzymes that can inactivate cefoperazone. Sulbactam acts as a suicide inhibitor of these beta-lactamases, protecting cefoperazone from degradation and significantly broadening its spectrum of activity. This synergistic combination is highly effective against a wide array of Gram-positive and Gram-negative bacteria, including many resistant strains that produce beta-lactamases. It is particularly valuable for treating severe and complicated infections in various body systems, such as intra-abdominal, respiratory, urinary tract, and skin and soft tissue infections, where broad-spectrum coverage and resistance overcoming capabilities are crucial.

Uses

• Intra-abdominal infections
• Respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections

Directions For Use

Administer intravenously or intramuscularly as directed by a healthcare professional.

Benefits

• Broad-spectrum antibacterial activity
• Effective against beta-lactamase producing bacteria
• Potent against Gram-positive and Gram-negative pathogens
• Useful for severe and complicated infections
• Good penetration into various body tissues
• Reduces bacterial resistance

Side Effects

• Diarrhea
• Nausea
• Vomiting
• Rash
• Injection site pain
• Fever
• Headache
• Dizziness
• Eosinophilia
• Transient liver enzyme elevation
• Hypoprothrombinemia (bleeding risk)
• Pseudomembranous colitis

Safety Measures

• Alcohol - Avoid alcohol during treatment and for several days after, as cefoperazone can cause a disulfiram-like reaction (flushing, nausea, vomiting, headache).
• Pregnancy - Use with caution and only if clearly indicated. Consult a doctor, as adequate and well-controlled studies in pregnant women are lacking.
• Breastfeeding - Both components are excreted in breast milk in small amounts. Use with caution; monitor the infant for gastrointestinal upset or rash.
• Liver - Use with caution in patients with significant liver disease or biliary obstruction, as cefoperazone is primarily excreted in bile.
• Kidney - Dose adjustment may be necessary in patients with severe renal impairment. Monitor renal function during treatment.
• Lung - Indicated for respiratory tract infections. No specific contraindications related to underlying lung conditions.

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