Cellmune 500mg Tablet

About

Mycophenolate mofetil is an immunosuppressant medication used to prevent organ rejection in patients who have received kidney, heart, or liver transplants. It works by inhibiting the proliferation of lymphocytes, specifically T and B cells, which are crucial components of the immune system responsible for mediating rejection responses. This selective action helps to suppress the immune system's attack on the transplanted organ, thereby improving graft survival rates. The drug is often used in combination with other immunosuppressants like corticosteroids and calcineurin inhibitors to achieve optimal immune suppression. Its mechanism involves the reversible inhibition of inosine monophosphate dehydrogenase (IMPDH), an enzyme essential for the de novo synthesis of guanosine nucleotides, which are required for lymphocyte proliferation. This targeted approach minimizes damage to other rapidly dividing cells.

Uses

• Prevention of organ rejection in kidney transplant recipients.
• Prevention of organ rejection in heart transplant recipients.
• Prevention of organ rejection in liver transplant recipients.
• Treatment of certain autoimmune diseases (off-label use).

Directions For Use

Take exactly as prescribed by your doctor, usually twice daily on an empty stomach. Do not crush, chew, or break the tablet.

Benefits

• Significantly reduces the risk of acute organ rejection.
• Improves long-term survival of transplanted organs.
• Effective in combination with other immunosuppressants.
• Helps maintain stable graft function.
• Reduces the need for high-dose corticosteroids.
• Offers a targeted immunosuppressive action.

Side Effects

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Leukopenia (low white blood cell count)
• Anemia
• Thrombocytopenia (low platelet count)
• Increased risk of infections (bacterial, viral, fungal)
• Increased risk of certain cancers (lymphoma, skin cancer)
• Headache
• Hypertension
• Tremor
• Insomnia

Safety Measures

• Alcohol - Avoid or limit alcohol consumption as it may increase the risk of gastrointestinal side effects and liver toxicity.
• Pregnancy - Highly teratogenic; contraindicated in pregnancy due to severe birth defects. Effective contraception is mandatory.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and harm the infant.
• Liver - Use with caution in patients with severe liver impairment; dose adjustments may be necessary.
• Kidney - Dose adjustments are typically required in patients with severe renal impairment.
• Lung - May rarely cause interstitial lung disease; monitor for new or worsening respiratory symptoms.

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