Celplat 10mg Injection

About

Celplat Injection is a potent antineoplastic agent belonging to the platinum-based chemotherapy class. Its primary mechanism of action involves forming highly reactive platinum complexes that bind to DNA, leading to the formation of intra-strand and inter-strand crosslinks. These DNA adducts distort the DNA structure, inhibiting DNA replication and transcription, which are critical processes for cell survival and proliferation. This damage triggers cellular apoptosis, particularly in rapidly dividing cancer cells, making it effective against a broad spectrum of solid tumors.

Administered intravenously, Celplat is known for its dose-limiting toxicities, particularly nephrotoxicity, ototoxicity, and severe nausea and vomiting. Therefore, its administration requires meticulous hydration protocols and antiemetic prophylaxis. It is widely used in combination with other chemotherapeutic agents or radiation therapy to enhance its efficacy. Careful monitoring of renal function, electrolytes, and audiometry is essential throughout the treatment course to manage and mitigate potential adverse effects.

Uses

• Treatment of testicular cancer
• Management of ovarian cancer
• Therapy for bladder cancer
• Used in head and neck cancers

Directions For Use

Celplat Injection is administered intravenously by a qualified healthcare professional. Pre-hydration and post-hydration protocols are crucial and must be followed as directed by the physician.

Benefits

• Highly effective against various solid tumors
• Induces significant DNA damage in cancer cells
• Often leads to tumor regression and disease control
• A cornerstone agent in many combination chemotherapy regimens
• Can improve survival rates in specific cancers
• Potentiates the effects of radiation therapy

Side Effects

• Severe nausea and vomiting
• Nephrotoxicity (kidney damage)
• Ototoxicity (hearing loss, tinnitus)
• Myelosuppression (anemia, leukopenia, thrombocytopenia)
• Peripheral neuropathy (numbness, tingling)
• Electrolyte disturbances (hypomagnesemia, hypokalemia)
• Anaphylactic-like reactions
• Fatigue
• Diarrhea or constipation
• Mucositis
• Hair thinning (less common than other agents)
• Liver enzyme elevations

Safety Measures

• Alcohol - Avoid alcohol during Celplat treatment as it may exacerbate nausea, vomiting, and liver toxicity.
• Pregnancy - Celplat is highly teratogenic and contraindicated in pregnancy. Effective contraception is mandatory for both partners.
• Breastfeeding - Breastfeeding is strictly contraindicated during Celplat therapy due to potential severe harm to the infant.
• Liver - Use with caution in patients with hepatic impairment; monitor liver function tests closely.
• Kidney - Celplat is highly nephrotoxic. Dose adjustments are crucial for renal impairment, and adequate hydration is mandatory.
• Lung - Monitor for pulmonary fibrosis or other lung toxicities, though less common, especially in patients with pre-existing lung disease.

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