Cistero 10mg Injection

About

Cistero 10mg Injection contains Cisplatin, a potent platinum-based chemotherapy agent used in the management of a wide range of solid tumors. Its mechanism of action involves forming strong cross-links within DNA strands, which disrupts DNA replication and transcription, ultimately leading to programmed cell death in rapidly dividing cancer cells. As a cell cycle non-specific agent, Cisplatin is effective against cells in various phases of the cell cycle, making it a powerful component in many multi-drug chemotherapy regimens.

Despite its efficacy, Cisplatin is associated with significant toxicities, including severe nausea and vomiting, kidney damage (nephrotoxicity), and hearing loss (ototoxicity). Therefore, its administration requires meticulous planning, including aggressive hydration protocols and prophylactic antiemetic therapy, to minimize adverse effects. It is always administered intravenously under the close supervision of oncology specialists in a clinical setting, with continuous monitoring of patient's renal function, electrolyte balance, and auditory status.

Uses

• Testicular cancer
• Ovarian cancer
• Bladder cancer
• Head and neck cancer

Directions For Use

This medicine is administered intravenously by a qualified healthcare professional.

Pre-hydration and antiemetic medication are typically given before administration.

Benefits

• Highly effective in treating several solid tumors
• Curative potential in germ cell tumors
• Often used as a cornerstone in combination regimens
• Can achieve significant tumor response
• Established efficacy in various cancer types
• Contributes to improved survival outcomes

Side Effects

• Severe nausea and vomiting
• Nephrotoxicity (kidney damage)
• Ototoxicity (hearing loss, tinnitus)
• Myelosuppression (low blood counts)
• Peripheral neuropathy (nerve damage)
• Electrolyte disturbances (hypomagnesemia, hypokalemia)
• Hypersensitivity reactions
• Alopecia (hair loss)
• Fatigue and weakness
• Anorexia (loss of appetite)
• Stomatitis (mouth sores)
• Hepatotoxicity (liver damage)

Safety Measures

• Alcohol - Avoid alcohol consumption during treatment with Cistero 10mg Injection as it may exacerbate side effects, particularly nausea and liver toxicity.
• Pregnancy - Cistero 10mg Injection is contraindicated in pregnancy due to its severe teratogenic and embryotoxic effects. Effective contraception is mandatory for both male and female patients during and for a period after treatment.
• Breastfeeding - Breastfeeding is contraindicated during treatment with Cistero 10mg Injection due to the potential for serious adverse reactions in the breastfed infant.
• Liver - Use with caution in patients with hepatic impairment. Liver function should be monitored, and dose adjustments may be considered.
• Kidney - Cistero 10mg Injection is highly nephrotoxic. It is contraindicated in severe renal impairment and requires careful monitoring of kidney function with extensive hydration in all patients.
• Lung - Rare cases of pulmonary fibrosis have been reported. Monitor for new or worsening respiratory symptoms, especially with prolonged use.

Disclaimer

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