Daxotel 80mg Injection

About

Daxotel Injection contains Docetaxel, a potent taxane antineoplastic agent widely used in the treatment of various solid tumors, including breast, non-small cell lung, prostate, gastric, and head and neck cancers. It exerts its cytotoxic effects by promoting the assembly of microtubules from tubulin dimers and inhibiting their depolymerization. This leads to the stabilization of microtubules, preventing normal cellular mitotic and interphase functions that are essential for cell division.

The disruption of the microtubule network is critical for cell division and other vital cellular processes, ultimately leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. Docetaxel is a cornerstone in the chemotherapy regimens for several advanced cancers, often used alone or in combination with other agents. Its efficacy stems from its ability to interfere with the dynamic equilibrium of microtubules, which are crucial for maintaining cell shape, motility, and intracellular transport, thereby effectively halting cancer cell proliferation.

Uses

• Breast cancer (adjuvant and metastatic)
• Non-small cell lung cancer
• Prostate cancer (hormone-refractory)
• Gastric adenocarcinoma
• Head and neck squamous cell carcinoma

Directions For Use

Administered intravenously by a healthcare professional, typically over one hour. Premedication is required to reduce hypersensitivity reactions.

Benefits

• Effective against a broad spectrum of solid tumors
• Improves progression-free and overall survival
• Can be used in combination with other chemotherapies
• Well-established efficacy in advanced cancers
• Manageable side effect profile with proper supportive care
• Offers a significant therapeutic option for many patients

Side Effects

• Myelosuppression (neutropenia, anemia, thrombocytopenia)
• Peripheral neuropathy (numbness, tingling)
• Fluid retention (edema)
• Hypersensitivity reactions (allergic reactions)
• Alopecia (hair loss)
• Nausea and vomiting
• Diarrhea or constipation
• Mucositis (mouth sores)
• Fatigue and asthenia
• Nail changes and skin reactions
• Muscle and joint pain
• Liver enzyme elevations

Safety Measures

• Alcohol - Avoid or limit alcohol due to potential for increased gastrointestinal irritation and liver strain, especially during chemotherapy.
• Pregnancy - Contraindicated during pregnancy due to significant risk of fetal harm. Effective contraception is essential for both male and female patients.
• Breastfeeding - Contraindicated. The drug may pass into breast milk and potentially harm the infant. Do not breastfeed during treatment.
• Liver - Use with extreme caution in patients with hepatic impairment; significant dosage reduction or discontinuation may be necessary. Monitor liver function closely.
• Kidney - Use with caution in patients with severe renal impairment; monitor renal function closely. Dosage adjustments may be considered.
• Lung - Monitor for interstitial lung disease or pneumonitis, though rare. Report any new or worsening respiratory symptoms promptly.

Disclaimer

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