About

Triptorelin is a synthetic decapeptide analogue of natural gonadotropin-releasing hormone (GnRH). Initially, it stimulates the pituitary gland to release gonadotropins (LH and FSH), but with continuous administration, it causes desensitization and downregulation of GnRH receptors, leading to a profound suppression of gonadotropin release. This results in a significant reduction in ovarian and testicular steroid production, effectively creating a reversible medical castration. It is used in conditions where suppression of sex hormones is therapeutically beneficial, such as hormone-dependent cancers and gynecological disorders. The depot formulation allows for extended release, reducing the frequency of injections and improving patient compliance while maintaining consistent hormonal suppression.

Uses

Treatment of prostate cancer.
Management of endometriosis.
Treatment of uterine fibroids.
Precocious puberty in children.

Directions For Use

Administer intramuscularly or subcutaneously as a depot injection, typically once every 28 days or as prescribed.

Benefits

Reduces sex hormone levels effectively.
Shrinks hormone-dependent tumors (e.g., prostate cancer).
Alleviates symptoms of endometriosis and fibroids.
Delays puberty in precocious cases.
Long-acting formulation reduces frequency of injections.
Provides a reversible medical castration effect.

Side Effects

Hot flashes
Sweating
Headache
Fatigue
Injection site reactions
Bone density loss (long-term)
Mood changes
Decreased libido
Vaginal dryness (women)
Testicular atrophy (men)
Nausea
Muscle pain

Safety Measures

Alcohol - No direct interaction; however, alcohol consumption should be moderate.
Pregnancy - Contraindicated in pregnancy due to potential harm to the fetus.
Breastfeeding - Contraindicated during breastfeeding.
Liver - Use with caution in patients with severe liver impairment; monitor closely.
Kidney - Use with caution in patients with severe kidney impairment; monitor closely.
Lung - Generally safe; no specific contraindications related to lung conditions.

Disclaimer

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