About

Triptorelin, a synthetic analogue of GnRH, initially stimulates the pituitary gland to release gonadotropins (LH and FSH). However, with continuous daily administration, it leads to desensitization and downregulation of GnRH receptors, resulting in a profound suppression of gonadotropin release. This suppression effectively reduces ovarian and testicular steroid production. The daily formulation is often used in assisted reproductive technologies (ART) to prevent premature ovulation, allowing for controlled ovarian stimulation. It can also be used in the initial phase of treatment for conditions requiring sex hormone suppression before switching to a depot form, or for diagnostic testing of pituitary function. Its precise daily dosing allows for fine-tuned hormonal control.

Uses

Prevention of premature LH surge in ART.
Initial phase of prostate cancer treatment.
Initial phase of endometriosis treatment.
Diagnostic testing for pituitary function.

Directions For Use

Administer subcutaneously once daily at the same time each day, as directed by a specialist.

Benefits

Prevents premature ovulation in IVF cycles.
Allows for controlled ovarian stimulation.
Initiates sex hormone suppression rapidly.
Flexible dosing for specific treatment protocols.
Helps achieve desired hormonal environment.
Supports successful outcomes in ART.

Side Effects

Injection site reactions
Headache
Hot flashes
Nausea
Abdominal pain
Fatigue
Mood swings
Breast tenderness
Ovarian hyperstimulation syndrome (in ART)
Vaginal bleeding
Muscle aches
Dizziness

Safety Measures

Alcohol - No direct interaction; however, alcohol consumption should be moderate.
Pregnancy - Contraindicated in pregnancy due to potential harm to the fetus.
Breastfeeding - Contraindicated during breastfeeding.
Liver - Use with caution in patients with severe liver impairment; monitor closely.
Kidney - Use with caution in patients with severe kidney impairment; monitor closely.
Lung - Generally safe; no specific contraindications related to lung conditions.

Disclaimer

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