About

Zavicefta is a combination antibiotic consisting of ceftazidime, a third-generation cephalosporin, and avibactam, a novel beta-lactamase inhibitor. This combination is designed to treat serious Gram-negative bacterial infections, particularly those caused by multi-drug resistant organisms, including carbapenem-resistant Enterobacteriaceae and Pseudomonas aeruginosa. Ceftazidime inhibits bacterial cell wall synthesis, while avibactam protects ceftazidime from degradation by a wide range of beta-lactamases, including Ambler class A, C, and some D enzymes.

This synergistic action restores ceftazidime's activity against resistant pathogens, making Zavicefta a crucial therapeutic option for complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired pneumonia.

Uses

Treatment of complicated intra-abdominal infections.
Management of complicated urinary tract infections.
Therapy for hospital-acquired bacterial pneumonia.
Treatment of ventilator-associated bacterial pneumonia.

Directions For Use

Administer intravenously by infusion over a specified period, as directed by a healthcare professional. Dosage is based on infection severity and renal function.

Benefits

Effective against multi-drug resistant Gram-negative bacteria.
Covers carbapenem-resistant Enterobacteriaceae.
Active against difficult-to-treat Pseudomonas aeruginosa.
Avibactam protects ceftazidime from degradation.
Crucial for severe hospital-acquired infections.
Offers a broad spectrum of activity against resistant pathogens.

Side Effects

Nausea
Vomiting
Diarrhea
Headache
Fever
Abdominal pain
Rash
Elevated liver enzymes
Injection site reactions
Dizziness
Insomnia
Clostridium difficile-associated diarrhea

Safety Measures

Alcohol - Generally safe, but avoid excessive alcohol consumption during antibiotic treatment to prevent gastrointestinal upset.
Pregnancy - Use only if clearly needed; consult a physician to weigh potential benefits against risks to the fetus.
Breastfeeding - Use with caution; small amounts may pass into breast milk, monitor infant for adverse effects.
Liver - No dose adjustment is typically required for hepatic impairment, but monitor liver function in severe cases.
Kidney - Dose adjustment is required for patients with renal impairment; closely monitor kidney function.
Lung - No specific contraindications; generally safe for individuals with lung conditions, but monitor for allergic reactions.

Disclaimer

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