WEMDAZOLE 100 ML INJ VIAL

About

WEMDAZOLE 100 ML INJ VIAL contains metronidazole, a synthetic nitroimidazole antimicrobial agent renowned for its potent activity against anaerobic bacteria and various protozoa. The drug's mechanism involves its entry into susceptible microorganisms, where it undergoes reductive activation by electron transport proteins. This reduction process generates highly reactive nitro radical anions that damage microbial DNA and other vital cellular components, ultimately leading to cell death. Metronidazole's selective toxicity against anaerobes and protozoa stems from their unique metabolic pathways that facilitate this reductive activation. It is a critical therapeutic agent for systemic infections, intra-abdominal sepsis, gynecological infections, skin and soft tissue infections, and parasitic diseases such as trichomoniasis, amebiasis, and giardiasis. Its intravenous formulation ensures rapid and effective systemic delivery, particularly in severe or hospitalized cases, making it indispensable in clinical practice.

Uses

• Treatment of anaerobic bacterial infections.
• Management of trichomoniasis.
• Therapy for amebiasis.
• Treatment of giardiasis.

Directions For Use

Administered intravenously as an infusion by a healthcare professional. Dosage and duration depend on the infection type and severity.

Benefits

• Broad spectrum against anaerobic bacteria.
• Effective against various protozoal infections.
• Good tissue penetration, including CNS.
• Available in intravenous form for severe infections.
• Can be used in combination with other antibiotics.
• Well-established efficacy in clinical practice.

Side Effects

• Nausea and vomiting
• Metallic taste in mouth
• Diarrhea
• Headache
• Dizziness
• Peripheral neuropathy (with prolonged use)
• Darkening of urine
• Abdominal cramps
• Rash
• Thrombophlebitis at injection site
• Seizures (rare)
• Leukopenia (reversible)

Safety Measures

• Alcohol - Avoid alcohol during and for at least 3 days after treatment due to a disulfiram-like reaction (nausea, vomiting, flushing, headache).
• Pregnancy - Generally avoided in the first trimester; use in later trimesters only if clearly needed and benefits outweigh risks.
• Breastfeeding - Not recommended during breastfeeding as it is excreted in breast milk; consider temporary cessation of breastfeeding.
• Liver - Use with caution in patients with severe hepatic impairment; dose reduction may be necessary.
• Kidney - Use with caution in patients with severe renal impairment; dose adjustment may be required.
• Lung - No specific contraindications related to lung conditions, but monitor for any unusual respiratory symptoms.

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