About

Cefoperazone/Sulbactam is a combination antibiotic consisting of a third-generation cephalosporin, cefoperazone, and a beta-lactamase inhibitor, sulbactam. Cefoperazone exerts its bactericidal action by inhibiting bacterial cell wall synthesis, primarily targeting penicillin-binding proteins. Sulbactam irreversibly inhibits a wide range of beta-lactamases, enzymes produced by bacteria that can inactivate cefoperazone. This combination broadens the spectrum of activity of cefoperazone to include many beta-lactamase-producing bacteria, making it effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic pathogens, particularly useful for serious infections.

The synergistic action of cefoperazone and sulbactam provides enhanced antimicrobial coverage, especially against resistant strains that produce beta-lactamases. This makes it a valuable option for treating complicated infections where resistance is a concern. Its broad spectrum and efficacy against various difficult-to-treat pathogens, including those causing nosocomial infections, underscore its importance in clinical practice. It is typically administered parenterally due to its formulation.

Uses

Treatment of respiratory tract infections.
Management of urinary tract infections.
Treatment of intra-abdominal infections.
Management of skin and soft tissue infections.

Directions For Use

Administered intravenously or intramuscularly by a healthcare professional. Dosage and duration depend on the infection severity and patient's condition.

Benefits

Broad spectrum of antibacterial activity.
Effective against beta-lactamase producing bacteria.
Useful for severe and complicated infections.
Covers both Gram-positive and Gram-negative pathogens.
Effective against anaerobic bacteria.
Good tissue penetration.

Side Effects

Diarrhea
Nausea
Vomiting
Rash
Pruritus
Fever
Injection site pain
Phlebitis
Eosinophilia
Transient elevations in liver enzymes
Hypoprothrombinemia (due to cefoperazone)
Pseudomembranous colitis (rare)

Safety Measures

Alcohol - Avoid alcohol consumption during and for several days after treatment due to the disulfiram-like reaction risk with cefoperazone.
Pregnancy - Use during pregnancy only if clearly needed and potential benefits outweigh risks. Consult a doctor.
Breastfeeding - Both components are excreted in breast milk. Use with caution; monitor infant for gastrointestinal disturbances.
Liver - Use with caution in patients with hepatic impairment or biliary obstruction. Dose adjustment may be necessary.
Kidney - Dose adjustment is generally not required for renal impairment alone, but combined hepatic and renal impairment needs careful consideration.
Lung - Generally safe for use in patients with lung conditions, as it does not directly affect respiratory function.

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