DURATAF 25MG TAB 30's

About

Durataf 25mg is an advanced antiviral medication, specifically a nucleotide reverse transcriptase inhibitor (NRTI), primarily used for the treatment of chronic Hepatitis B virus (HBV) infection and HIV-1 infection. It is a prodrug of tenofovir, designed to deliver the active drug more efficiently to target cells, particularly hepatocytes and lymphocytes, with lower systemic exposure. This targeted delivery results in potent antiviral activity at a lower dose, leading to fewer renal and bone-related side effects compared to older tenofovir formulations.

Durataf works by inhibiting the reverse transcriptase enzyme, which is vital for the replication of both HBV and HIV. By blocking this enzyme, it effectively reduces viral load, prevents disease progression, and minimizes the risk of long-term complications such as liver cirrhosis, hepatocellular carcinoma, and AIDS-related conditions. It is often part of a combination therapy regimen for HIV and provides long-term viral control for HBV. Consistent adherence and regular monitoring are crucial for optimal therapeutic outcomes.

Uses

• Treatment of chronic Hepatitis B virus (HBV) infection.
• Treatment of HIV-1 infection in adults and adolescents.
• Suppression of HBV DNA and HIV RNA levels.
• Prevention of HBV and HIV-related disease progression.

Directions For Use

Take one tablet orally once daily with food, as directed by your healthcare provider. Do not discontinue without medical advice.

Benefits

• Highly effective in suppressing HBV and HIV viral loads.
• Improved renal and bone safety profile compared to older formulations.
• Convenient once-daily dosing.
• Prevents progression of liver disease in HBV.
• Reduces risk of HIV-related complications.
• Enhances overall patient health and longevity.

Side Effects

• Nausea
• Abdominal pain
• Diarrhea
• Headache
• Fatigue
• Dizziness
• Flatulence
• Elevated liver enzymes
• Rash
• Lactic acidosis (rare)
• Kidney impairment (less common)
• Bone density changes (less common)

Safety Measures

• Alcohol - Limit alcohol intake as it can exacerbate liver damage, especially in patients with HBV, and may worsen gastrointestinal side effects.
• Pregnancy - Consult a doctor. Use only if the potential benefit justifies the potential risk to the fetus. Discuss with a healthcare provider for individualized advice.
• Breastfeeding - Consult a doctor. Breastfeeding is generally not recommended for mothers with HIV due to the risk of viral transmission. For HBV, discuss with a physician.
• Liver - Use with caution in patients with pre-existing liver disease; monitor liver function closely. May cause exacerbation of HBV upon discontinuation.
• Kidney - While generally safer for kidneys, monitor renal function periodically, especially in patients with pre-existing kidney impairment.
• Lung - No specific direct lung effects, but any new or worsening respiratory symptoms should be evaluated by a healthcare professional.

Disclaimer

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