About
Ursodeoxycholic Acid (UDCA), also known as ursodiol, is a naturally occurring bile acid used to treat various liver and gallbladder conditions. It works by altering the composition of bile, reducing the cholesterol content and making it less lithogenic (stone-forming). UDCA helps to dissolve cholesterol gallstones and prevent their formation.
In chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC), UDCA improves bile flow, protects liver cells from toxic bile acids, and reduces inflammation. Its hepatoprotective effects are attributed to its ability to stabilize cell membranes, modulate immune responses, and promote the excretion of harmful substances from the liver, thereby slowing disease progression and improving liver function and overall prognosis.
Uses
- Dissolution of small to medium cholesterol gallstones.
- Treatment of primary biliary cholangitis (PBC).
- Management of cholestatic liver diseases.
- Prevention of gallstone formation in certain conditions.
Directions For Use
Take orally, usually with food, as directed by your physician. Dosage and duration vary based on the condition being treated.
Benefits
- Effectively dissolves cholesterol gallstones.
- Slows the progression of primary biliary cholangitis.
- Improves liver function in cholestatic conditions.
- Reduces symptoms like pruritus (itching) in PBC.
- Protects liver cells from toxic bile acids.
- Generally well-tolerated for long-term use.
Side Effects
- Diarrhea
- Nausea
- Abdominal pain
- Constipation
- Indigestion
- Headache
- Dizziness
- Rash
- Hair thinning
- Vomiting
- Back pain
- Arthralgia
Safety Measures
- Alcohol - Avoid or limit alcohol consumption as it can worsen liver conditions and potentially reduce the effectiveness of UDCA.
- Pregnancy - Use during pregnancy only if clearly needed and the potential benefit justifies the potential risk to the fetus.
- Breastfeeding - Small amounts may pass into breast milk; use with caution and consult a healthcare provider.
- Liver - Used to treat liver conditions; however, it should not be used in acute inflammation of the gallbladder or bile ducts.
- Kidney - Generally considered safe for use in patients with kidney conditions; no specific dosage adjustment is usually required.
- Lung - No specific contraindications or precautions related to lung conditions are generally noted for this medication.
Disclaimer
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Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.
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