Docax 120mg Injection

About

Docax 120mg Injection is an antineoplastic agent belonging to the taxane class, primarily utilized in the systemic treatment of various solid tumors. Its mechanism of action involves promoting the assembly of microtubules and inhibiting their depolymerization, leading to the stabilization of microtubules. This disruption of the dynamic equilibrium of the microtubule network is essential for vital cellular functions, including mitosis and interphase processes. Consequently, Docax arrests cells in the G2/M phase of the cell cycle, ultimately inducing apoptosis in rapidly proliferating cancer cells. Administered intravenously, its therapeutic efficacy is dependent on precise dosing and careful management of potential adverse effects, often requiring premedication to mitigate hypersensitivity reactions.

The drug is a potent cytotoxic agent, and its use is typically reserved for specific indications where its benefits outweigh the risks. It is often incorporated into multi-drug chemotherapy regimens or used as a monotherapy in patients who have failed other treatments. Regular monitoring of blood counts and liver function is crucial during therapy to ensure patient safety and optimize treatment outcomes. The 120mg strength provides a higher dose option, suitable for specific treatment protocols and patient body surface areas.

Uses

• Treatment of advanced breast cancer.
• Management of non-small cell lung cancer.
• Therapy for hormone-refractory prostate cancer.
• Treatment of gastric adenocarcinoma.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and infusion rate are determined by the patient's body surface area and specific treatment protocol.

Benefits

• Effective against a broad spectrum of solid tumors.
• Can be used as a first-line or subsequent-line therapy.
• May improve progression-free and overall survival.
• Induces tumor regression in responsive cancers.
• Established efficacy in various clinical settings.
• Available in a convenient injectable formulation.

Side Effects

• Myelosuppression (neutropenia, anemia, thrombocytopenia).
• Peripheral neuropathy (numbness, tingling).
• Fluid retention (edema, pleural effusion).
• Hypersensitivity reactions (rash, flushing, dyspnea).
• Nausea and vomiting.
• Alopecia (hair loss).
• Mucositis (inflammation of mucous membranes).
• Diarrhea.
• Fatigue and asthenia.
• Nail changes (discoloration, brittleness).
• Muscle and joint pain (arthralgia, myalgia).
• Liver enzyme elevations.

Safety Measures

• Alcohol - Avoid alcohol consumption due to potential for increased liver toxicity and gastrointestinal irritation, especially during chemotherapy.
• Pregnancy - Contraindicated in pregnancy; can cause severe fetal harm. Women of childbearing potential must use effective contraception during and after treatment.
• Breastfeeding - Not recommended during treatment and for a period thereafter, as the drug may pass into breast milk and harm the infant.
• Liver - Use with extreme caution; dose adjustments are often necessary in patients with hepatic impairment due to altered drug metabolism and increased toxicity risk.
• Kidney - Generally safe, but monitor renal function. No specific dose adjustment is typically required for mild to moderate renal impairment.
• Lung - Monitor for signs of interstitial lung disease or pneumonitis; use with caution in patients with pre-existing pulmonary conditions.

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