Docecad 120mg Injection

About

Docetaxel is a potent antineoplastic agent belonging to the taxoid class, primarily used in the treatment of various solid tumors. It exerts its cytotoxic effects by promoting the assembly of microtubules from tubulin dimers and simultaneously inhibiting their depolymerization, leading to the stabilization of microtubules. This action disrupts the normal dynamic reorganization of the microtubule network, which is essential for vital cellular interphase and mitotic functions. Consequently, docetaxel arrests cells in the G2/M phase of the cell cycle and induces apoptosis, thereby inhibiting tumor cell proliferation. It is administered intravenously and requires careful monitoring due to its narrow therapeutic index and potential for significant side effects.

Uses

• Treatment of breast cancer
• Management of non-small cell lung cancer
• Therapy for hormone-refractory prostate cancer
• Treatment of advanced gastric adenocarcinoma

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and schedule are determined by the patient's condition, cancer type, and body surface area.

Benefits

• Effective against a broad spectrum of solid tumors
• Improves progression-free survival in various cancers
• Well-established and widely used chemotherapy agent
• Can be used as monotherapy or in combination regimens
• Offers a treatment option for advanced or metastatic disease
• Contributes to disease control and symptom palliation

Side Effects

• Neutropenia (low white blood cell count)
• Peripheral neuropathy (nerve damage)
• Fluid retention (edema)
• Hypersensitivity reactions
• Alopecia (hair loss)
• Nausea and vomiting
• Diarrhea
• Mucositis (inflammation of mucous membranes)
• Fatigue and asthenia
• Nail changes (discoloration, brittleness)
• Skin reactions (rash, redness)
• Anemia (low red blood cell count)

Safety Measures

• Alcohol - Alcohol consumption should be avoided or minimized during docetaxel treatment due to potential liver strain and increased risk of adverse effects.
• Pregnancy - Docetaxel is contraindicated in pregnancy due to its teratogenic and embryotoxic potential. Effective contraception must be used by patients of reproductive potential.
• Breastfeeding - Breastfeeding is contraindicated during docetaxel therapy as the drug is likely excreted in human milk and could cause serious adverse reactions in the infant.
• Liver - Patients with hepatic impairment require dose reduction and careful monitoring due to increased risk of toxicity. Severe liver dysfunction is a contraindication.
• Kidney - Use with caution in patients with renal impairment. While not primarily renally cleared, close monitoring of kidney function is advisable.
• Lung - Docetaxel can rarely cause interstitial lung disease or acute respiratory distress syndrome. Monitor for new or worsening pulmonary symptoms.

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