Docedel 80mg Injection

About

Docetaxel is an antineoplastic agent belonging to the taxoid class, primarily used in the treatment of various cancers. It functions by disrupting the microtubule network in cells, which is essential for mitotic and interphase cellular functions. Specifically, docetaxel promotes the assembly of microtubules from tubulin dimers and stabilizes them by preventing depolymerization. This leads to the inhibition of cell division and ultimately induces apoptosis in rapidly dividing cancer cells. Its mechanism of action makes it effective against a broad spectrum of solid tumors.

This cytotoxic agent is administered intravenously and undergoes hepatic metabolism. Due to its potent cytotoxic effects, careful monitoring of patients for adverse reactions, particularly myelosuppression, fluid retention, and hypersensitivity reactions, is crucial during treatment. The dosage and administration schedule are tailored based on the specific cancer type, patient's body surface area, and overall health status, often requiring premedication to mitigate certain side effects.

Uses

• Treatment of breast cancer.
• Management of non-small cell lung cancer.
• Therapy for prostate cancer.
• Treatment of gastric adenocarcinoma.

Directions For Use

Administered intravenously by a healthcare professional. Dosage and schedule are determined by your doctor.

Benefits

• Effective against various solid tumors.
• Can improve progression-free survival.
• May lead to tumor regression.
• Offers a treatment option for advanced cancers.
• Part of established chemotherapy regimens.
• Can improve quality of life in some patients.

Side Effects

• Bone marrow suppression (neutropenia, anemia, thrombocytopenia)
• Fluid retention (edema, pleural effusion)
• Hypersensitivity reactions
• Peripheral neuropathy
• Nausea and vomiting
• Diarrhea
• Alopecia (hair loss)
• Fatigue and weakness
• Muscle and joint pain
• Skin reactions (rash, nail changes)
• Mucositis (mouth sores)
• Liver enzyme elevations

Safety Measures

• Alcohol - Avoid alcohol during treatment as it can exacerbate liver toxicity and other side effects. Consult your doctor.
• Pregnancy - Docetaxel is contraindicated in pregnancy due to potential fetal harm. Effective contraception is required during treatment.
• Breastfeeding - Breastfeeding is not recommended during docetaxel treatment due to the potential for serious adverse reactions in the infant.
• Liver - Use with caution in patients with liver impairment; dose adjustments may be necessary due to altered metabolism and increased toxicity risk.
• Kidney - Use with caution in patients with severe kidney impairment; close monitoring is advised, though renal excretion is not a primary elimination route.
• Lung - Monitor for pulmonary toxicity, including interstitial pneumonia or acute respiratory distress syndrome, especially in patients with pre-existing lung conditions.

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