Docefect RTU 20mg Injection

About

Docefect RTU 20mg Injection contains Docetaxel, a taxane antineoplastic agent that functions by interfering with the normal dynamics of cellular microtubules. It promotes the assembly of tubulin into stable microtubules and simultaneously inhibits their depolymerization, leading to an accumulation of non-functional microtubules within the cell. This disruption arrests the cell cycle in the G2/M phase, preventing cell division and ultimately inducing apoptosis in rapidly proliferating cancer cells. The "Ready To Use" formulation simplifies preparation and administration, ensuring consistent dosing and reducing potential handling errors, making it a convenient and effective option for various cancer treatments.

Uses

• Treatment of metastatic breast cancer.
• Management of non-small cell lung cancer.
• Treatment of prostate cancer.
• Management of gastric adenocarcinoma.

Directions For Use

Administer intravenously by a qualified healthcare professional, typically as a 1-hour infusion, with premedication to reduce hypersensitivity reactions.

Benefits

• Ready-to-use formulation simplifies preparation.
• Reduces potential for handling errors.
• Effective against a broad spectrum of solid tumors.
• Induces apoptosis in rapidly dividing cancer cells.
• Can be used as monotherapy or in combination regimens.
• Well-established efficacy in various treatment lines.

Side Effects

• Myelosuppression (neutropenia, anemia, thrombocytopenia)
• Hypersensitivity reactions
• Fluid retention (edema)
• Peripheral neuropathy
• Alopecia (hair loss)
• Nausea and vomiting
• Diarrhea
• Stomatitis/mucositis
• Fatigue/asthenia
• Nail changes
• Skin reactions
• Muscle and joint pain

Safety Measures

• Alcohol - Alcohol should be strictly avoided during treatment as it can exacerbate gastrointestinal side effects and may interact with the drug's metabolism.
• Pregnancy - This medication is contraindicated in pregnancy due to its genotoxic and teratogenic potential; effective contraception is mandatory during treatment.
• Breastfeeding - Breastfeeding is contraindicated during treatment and for a period after the last dose due to the potential for serious adverse effects on the infant.
• Liver - Dose adjustments are crucial for patients with hepatic impairment, and liver function should be closely monitored due to the drug's metabolism and excretion.
• Kidney - No specific dose adjustment is typically required for renal impairment, but caution is advised, and renal function should be monitored.
• Lung - Patients should be monitored for signs of pulmonary toxicity, such as interstitial pneumonia or acute respiratory distress syndrome, though these are rare.

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