Docemax 120mg Injection

About

Docetaxel, marketed under various brand names like Docemax, Docemaps, and Docefect RTU, is a potent antineoplastic agent belonging to the taxane class of chemotherapy drugs. It exerts its cytotoxic effects by promoting the assembly of microtubules from tubulin dimers and simultaneously inhibiting their depolymerization, leading to the stabilization of microtubules. This action disrupts the normal dynamic reorganization of the microtubule network essential for vital interphase and mitotic cellular functions, ultimately arresting cell division and inducing apoptosis in rapidly proliferating cancer cells. It is administered intravenously for the treatment of various solid tumors, often as part of a comprehensive cancer treatment plan, and requires careful patient monitoring due to its potent effects.

Uses

• Treatment of advanced breast cancer.
• Management of non-small cell lung cancer.
• Therapy for hormone-refractory prostate cancer.
• Used in advanced gastric adenocarcinoma.

Directions For Use

Administered intravenously by a qualified healthcare professional. Premedication with corticosteroids is typically required to reduce hypersensitivity reactions.

Benefits

• Proven efficacy against several solid tumors.
• Significantly slows tumor growth and progression.
• Can improve overall survival rates in patients.
• Effective as a monotherapy or in combination regimens.
• Provides palliative care for advanced metastatic disease.
• Well-established and widely used chemotherapy agent.

Side Effects

• Myelosuppression (low white blood cells, anemia).
• Peripheral neuropathy (numbness, tingling).
• Fluid retention (edema).
• Alopecia (hair loss).
• Nausea and vomiting.
• Diarrhea.
• Severe fatigue and asthenia.
• Mucositis (mouth sores).
• Skin reactions (rash, redness).
• Nail changes.
• Hypersensitivity reactions.
• Muscle and joint pain.

Safety Measures

• Alcohol - Avoid alcohol consumption during treatment due to potential liver toxicity and interaction with premedication, which may contain alcohol.
• Pregnancy - Docetaxel is contraindicated during pregnancy as it can cause severe fetal harm; effective contraception is required for both male and female patients.
• Breastfeeding - Breastfeeding is contraindicated during Docetaxel treatment due to the unknown excretion into breast milk and potential serious adverse effects on the infant.
• Liver - Contraindicated in patients with severe hepatic impairment; dose reductions are necessary for moderate impairment, and liver function must be closely monitored.
• Kidney - Use with caution in patients with renal impairment; monitor kidney function closely, though specific dose adjustment guidelines are not well-established.
• Lung - Monitor for signs of interstitial lung disease, pneumonitis, or acute respiratory distress syndrome, especially in patients with pre-existing lung conditions.

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