Emetant IV 150mg Injection

About

Emetant IV 150mg Injection is a highly effective antiemetic belonging to the class of Neurokinin-1 (NK1) receptor antagonists. Its primary mechanism of action involves selectively blocking the binding of substance P, a neuropeptide, to the NK1 receptors in the central nervous system. Substance P plays a crucial role in the emetic reflex, particularly in mediating delayed chemotherapy-induced nausea and vomiting (CINV). By inhibiting this pathway, Emetant significantly reduces both acute and, more notably, delayed CINV, which can be particularly challenging to manage.

Administered intravenously, often as a single dose, this medication is typically used in combination with other antiemetics, such as 5-HT3 receptor antagonists and corticosteroids, to provide comprehensive protection against chemotherapy-induced emesis. Its long duration of action contributes to sustained antiemetic control over several days, which is vital for patients undergoing highly emetogenic chemotherapy regimens. Emetant represents a significant advancement in supportive care, improving patient comfort and adherence to cancer treatment protocols.

Uses

• Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)
• Used in conjunction with other antiemetics for highly emetogenic chemotherapy
• Prevention of post-operative nausea and vomiting (PONV)
• Management of moderately emetogenic chemotherapy-induced emesis

Directions For Use

Administer intravenously by a healthcare professional, typically as a single dose prior to chemotherapy.

Benefits

• Highly effective for preventing delayed CINV
• Synergistic when used with 5-HT3 antagonists and corticosteroids
• Provides a long duration of antiemetic action
• Significantly improves overall CINV control
• Reduces the need for rescue antiemetic medications
• Enhances patient comfort and quality of life during chemotherapy

Side Effects

• Fatigue
• Hiccups
• Headache
• Constipation
• Dizziness
• Dyspepsia (indigestion)
• Injection site reactions
• Neutropenia (low white blood cell count)
• Anorexia (loss of appetite)
• Weakness
• Skin rash
• Abdominal pain

Safety Measures

• Alcohol - No specific interaction with alcohol is known. However, it is generally advisable to avoid alcohol if feeling unwell or experiencing nausea.
• Pregnancy - Consult your doctor before use during pregnancy. It should only be used if the potential benefits clearly justify the potential risks to the fetus.
• Breastfeeding - Consult your doctor. It is unknown if the medication is excreted in breast milk, and potential effects on the infant are not fully established.
• Liver - Use with caution in patients with severe liver impairment. Dose adjustment may be necessary due to altered drug metabolism.
• Kidney - Generally considered safe for use in patients with kidney conditions. No specific dose adjustment is usually required for renal impairment.
• Lung - Generally safe for use in patients with lung conditions. No specific lung concerns or adverse effects are typically associated with this medication.

Disclaimer

MedEHub is committed to delivering reliable, expert-reviewd information to help consumers make informed health decisions. However, the content provided on this website is for informational purposes only and is not intended to replace professional medical advice, diagnosis or treatment.

Always consult your doctor for any medical concerns, and discuss your questions about health conditions or medications with a qualified healthcare professional. Do not ignore or delay seeking professional medical advice based on information found on Med E Hub.

Our goal is to complement, not replace, the essential doctor-patient relationship.