EMPAGLOXIT 10MG 10S

About

Empagliflozin is a potent sodium-glucose co-transporter 2 (SGLT2) inhibitor that operates by blocking the reabsorption of glucose in the renal tubules, leading to increased glucose excretion in the urine. This unique mechanism effectively lowers blood glucose levels in adults with type 2 diabetes mellitus, independent of insulin secretion. Beyond its primary role in glycemic control, empagliflozin has demonstrated remarkable benefits in reducing the risk of cardiovascular death and hospitalization for heart failure in patients with established cardiovascular disease or heart failure. Furthermore, it significantly slows the progression of chronic kidney disease, offering comprehensive cardiorenal protection. It is typically prescribed as an adjunct to diet and exercise, either as monotherapy or in combination with other antidiabetic agents, to improve overall health outcomes.

Uses

• Management of type 2 diabetes mellitus.
• Reduction of cardiovascular death in adults with type 2 diabetes and established cardiovascular disease.
• Reduction of hospitalization for heart failure in adults.
• Reduction of the risk of kidney disease progression in adults with chronic kidney disease.

Directions For Use

Take orally once daily in the morning, with or without food, as directed by your physician. Swallow the tablet whole with water.

Benefits

• Effective blood glucose control.
• Reduces risk of major cardiovascular events.
• Lowers risk of hospitalization for heart failure.
• Slows progression of chronic kidney disease.
• May lead to modest weight loss.
• Generally well-tolerated.

Side Effects

• Urinary tract infections (UTIs)
• Genital yeast infections
• Increased urination
• Thirst
• Nausea
• Constipation
• Dizziness
• Hypotension (low blood pressure)
• Ketoacidosis (rare but serious)
• Kidney problems (rare)
• Fournier's gangrene (very rare)
• Hypoglycemia (when used with insulin/sulfonylureas)

Safety Measures

• Alcohol - Use alcohol cautiously as it may increase the risk of hypoglycemia or ketoacidosis.
• Pregnancy - Generally not recommended during pregnancy, especially in the second and third trimesters, due to potential fetal kidney effects.
• Breastfeeding - Not recommended during breastfeeding as it may pass into breast milk and affect the infant.
• Liver - Generally safe, but use with caution in severe hepatic impairment; no dose adjustment typically needed for mild-moderate.
• Kidney - Dose adjustment may be required based on eGFR; not recommended for severe renal impairment or end-stage renal disease.
• Lung - No specific contraindications or dose adjustments related to lung conditions.

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