About
JARDIANCE (empagliflozin) is an oral medication belonging to the class of sodium-glucose co-transporter 2 (SGLT2) inhibitors. It is primarily used to improve glycemic control in adults with type 2 diabetes mellitus. Empagliflozin works by blocking the SGLT2 protein in the kidneys, which is responsible for reabsorbing glucose back into the bloodstream. By inhibiting this protein, Jardiance causes the kidneys to excrete more glucose in the urine, thereby lowering blood glucose levels. Beyond its glucose-lowering effects, Jardiance has demonstrated significant cardiovascular benefits, including a reduction in the risk of cardiovascular death, and renal benefits, slowing the progression of kidney disease in patients with type 2 diabetes.
Uses
- Treatment of type 2 diabetes mellitus
- Reduction of cardiovascular death in adults with T2DM and established CVD
- Reduction of risk of hospitalization for heart failure
- Reduction of risk of kidney disease progression in T2DM patients
Directions For Use
Take orally once daily in the morning, with or without food, as prescribed by your physician. Do not crush or chew the tablet.
Benefits
- Effectively lowers blood glucose levels
- Reduces HbA1c (average blood sugar)
- Aids in modest weight loss
- Contributes to lower blood pressure
- Reduces risk of major cardiovascular events
- Slows the progression of chronic kidney disease
Side Effects
- Urinary tract infections
- Genital yeast infections
- Increased urination and thirst
- Low blood pressure (hypotension)
- Dizziness or lightheadedness
- Kidney problems (e.g., acute kidney injury)
- Diabetic ketoacidosis (rare but serious)
- Leg or foot amputation (very rare)
- Fournier's gangrene (very rare)
- Allergic reactions
- Nausea and constipation
- Fatigue and back pain
Safety Measures
- Alcohol - Limit alcohol intake, as it can increase the risk of ketoacidosis and hypoglycemia, especially with Jardiance.
- Pregnancy - Not recommended during the second and third trimesters; consult your doctor immediately if you become pregnant.
- Breastfeeding - Not recommended; empagliflozin may pass into breast milk and could harm a nursing infant.
- Liver - Use with caution in severe hepatic impairment; no dose adjustment typically needed for mild-to-moderate impairment.
- Kidney - Contraindicated in severe renal impairment or end-stage renal disease; dose adjustment may be needed based on eGFR.
- Lung - Generally safe; no specific lung-related precautions or direct pulmonary effects are typically associated with Jardiance.
Disclaimer
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