ESOKEM D TAB 10

About

Esokem D represents a synergistic combination medication engineered to comprehensively address both excessive gastric acid secretion and impaired gastrointestinal motility. It integrates esomeprazole, a highly effective proton pump inhibitor (PPI), with domperidone, a potent prokinetic agent. Esomeprazole, specifically the S-isomer of omeprazole, exerts its therapeutic effect by irreversibly inhibiting the H+/K+-ATPase pump within the gastric parietal cells. This action leads to a profound and sustained reduction in stomach acid production, providing robust relief from acid-related symptoms and promoting the healing of acid-induced esophageal and gastric damage. Domperidone, acting as a peripheral dopamine D2 receptor antagonist, enhances gastrointestinal motility by increasing the tone of the lower esophageal sphincter and accelerating gastric emptying, thereby reducing symptoms like nausea, vomiting, bloating, and early satiety. This dual-action formulation is particularly beneficial for patients suffering from gastroesophageal reflux disease (GERD) or dyspepsia where both acid hypersecretion and motility disturbances contribute to their clinical presentation, offering comprehensive symptomatic control and improved digestive function.

Uses

• Gastroesophageal Reflux Disease (GERD) with associated nausea/vomiting
• Dyspepsia with impaired gastric emptying
• Erosive Esophagitis with motility issues
• Zollinger-Ellison Syndrome with prokinetic needs

Directions For Use

Take once daily, preferably before a meal, or as directed by your physician. Swallow the tablet whole.

Benefits

• Potent reduction of stomach acid.
• Enhances gastric emptying.
• Relieves heartburn, acid reflux, and nausea.
• Reduces bloating and discomfort.
• Promotes healing of esophageal lesions.
• Addresses both acid and motility issues.

Side Effects

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Flatulence
• Dizziness
• Dry mouth
• Constipation
• Rash
• Somnolence (drowsiness)
• Galactorrhea (rare, due to domperidone)
• QT prolongation (rare, due to domperidone)

Safety Measures

• Alcohol - Moderate alcohol consumption is generally acceptable, but excessive intake may worsen acid reflux symptoms.
• Pregnancy - Use only if clearly needed; consult a doctor. Limited data available for both components.
• Breastfeeding - Not recommended as both components are excreted in breast milk and domperidone may affect the infant.
• Liver - Use with caution; dose adjustment may be necessary, especially for domperidone.
• Kidney - Use with caution; dose adjustment may be necessary, especially for domperidone.
• Lung - Domperidone should be used with caution in patients with underlying cardiac conditions due to potential for QT prolongation.

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