About

Domperidone is a dopamine antagonist that functions as both a prokinetic agent and an antiemetic. Its primary action involves blocking dopamine receptors located in the chemoreceptor trigger zone (CTZ) in the brain and within the gastrointestinal tract. This dual action leads to several therapeutic effects: in the GI tract, it increases the tone of the lower esophageal sphincter and enhances gastric and intestinal motility, thereby accelerating gastric emptying and reducing symptoms of reflux.

In the CTZ, its blocking effect effectively suppresses nausea and vomiting induced by various stimuli, including certain medications or conditions like gastroparesis. Domperidone is particularly useful for managing symptoms associated with dyspepsia, gastroparesis, and nausea, offering relief without readily crossing the blood-brain barrier, thus minimizing central nervous system side effects.

Uses

Relief of nausea and vomiting
Treatment of dyspepsia
Management of gastroparesis
Alleviation of reflux symptoms

Directions For Use

Take 15-30 minutes before meals, or as directed by your physician. Do not exceed the recommended dose.

Benefits

Effectively reduces nausea and vomiting.
Accelerates gastric emptying.
Alleviates symptoms of bloating and fullness.
Improves upper gastrointestinal motility.
Provides relief from indigestion.
Low potential for blood-brain barrier penetration.

Side Effects

Dry mouth
Headache
Dizziness
Abdominal cramps
Diarrhea
Skin rash
Galactorrhea (rare)
Gynecomastia (rare)
Arrhythmias (rare, with high doses/risk factors)
Anxiety
Insomnia
Lethargy

Safety Measures

Alcohol - Alcohol can exacerbate gastrointestinal symptoms and may increase the risk of side effects like dizziness; avoid or limit consumption.
Pregnancy - Consult a doctor before use during pregnancy; generally not recommended unless potential benefits outweigh risks.
Breastfeeding - Consult a doctor before use during breastfeeding; domperidone passes into breast milk, but typically in small amounts.
Liver - Use with caution in patients with moderate to severe liver impairment; dosage adjustments may be necessary.
Kidney - Use with caution in patients with moderate to severe kidney impairment; dosage adjustments may be necessary.
Lung - No direct contraindications for lung conditions, but always inform your doctor about all existing health issues.

Disclaimer

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