ESPRA DSR TAB 10'S

About

ESPRA DSR combines Esomeprazole, a proton pump inhibitor (PPI), with Domperidone, a dopamine antagonist and prokinetic agent. Esomeprazole works by irreversibly blocking the H+/K+-ATPase enzyme system (proton pump) in gastric parietal cells, thereby significantly reducing gastric acid secretion. This action is crucial for healing acid-related damage and alleviating symptoms like heartburn. Domperidone acts by blocking dopamine receptors in the chemoreceptor trigger zone and in the gastrointestinal tract, which enhances gastric motility, accelerates gastric emptying, and reduces nausea and vomiting. This combination provides comprehensive relief from symptoms associated with both excessive acid reflux and impaired gastrointestinal motility, offering a dual approach to managing complex upper digestive issues.

Uses

• Treatment of gastroesophageal reflux disease (GERD).
• Management of dyspepsia (indigestion).
• Relief from nausea and vomiting.
• Healing of peptic ulcers.

Directions For Use

Take orally once daily, preferably before a meal, usually in the morning, as directed by your healthcare provider.

Benefits

• Effectively reduces stomach acid production.
• Alleviates heartburn and acid reflux symptoms.
• Improves gastric emptying and motility.
• Controls nausea and vomiting.
• Provides sustained relief from digestive discomfort.
• Aids in the healing of esophageal erosions and ulcers.

Side Effects

• Headache
• Diarrhea
• Nausea
• Abdominal pain
• Flatulence
• Dry mouth
• Dizziness
• Constipation
• Skin rash
• Gynecomastia (Domperidone)
• QT prolongation (Domperidone, rare)
• Vitamin B12 deficiency (long-term PPI use)

Safety Measures

• Alcohol - Alcohol may irritate the stomach lining and potentially worsen symptoms, counteracting the medication's effects. Moderate intake is advised.
• Pregnancy - Use with caution during pregnancy. Consult your doctor to weigh the potential benefits against any risks to the fetus.
• Breastfeeding - Domperidone passes into breast milk. Use with caution, and consult your doctor before breastfeeding while on this medication.
• Liver - Use with caution in patients with liver impairment. Dosage adjustments may be necessary, especially for Domperidone, due to altered metabolism.
• Kidney - Use with caution in patients with severe renal impairment. Dosage adjustments may be required, particularly for Domperidone.
• Lung - No direct specific interaction. However, effective management of GERD can reduce the risk of aspiration-related lung complications.

Disclaimer

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