ETOVEL 100 MG INJ. VIAL.

About

Etoposide is a potent topoisomerase II inhibitor, a crucial class of chemotherapy drugs employed in the management of various neoplastic diseases. It exerts its cytotoxic effects by forming a ternary complex with topoisomerase II and DNA, thereby preventing the re-ligation of DNA strands after cleavage. This interference with DNA synthesis and repair mechanisms leads to the accumulation of DNA strand breaks, ultimately triggering cell cycle arrest in the S and G2 phases and inducing apoptosis in rapidly proliferating cancer cells. Administered intravenously, etoposide is a cornerstone in combination regimens for several malignancies, leveraging its ability to disrupt cellular replication and promote programmed cell death, thereby contributing to tumor regression and disease control.

Uses

• Small cell lung cancer
• Testicular cancer
• Lymphoma
• Leukemia

Directions For Use

Administered intravenously by a healthcare professional. Dosage and frequency are determined by the physician based on the patient's condition.

Benefits

• Effective against various solid tumors and hematologic malignancies.
• Can be used in combination chemotherapy regimens.
• Available in intravenous formulation for systemic delivery.
• Established efficacy in relapsed or refractory settings.
• Contributes to disease remission and improved survival rates.
• Part of standard treatment protocols for specific cancers.

Side Effects

• Myelosuppression (low blood counts)
• Nausea and vomiting
• Alopecia (hair loss)
• Fatigue
• Anorexia
• Diarrhea
• Mucositis
• Peripheral neuropathy
• Hypotension (with rapid infusion)
• Allergic reactions
• Liver enzyme elevation
• Secondary malignancies (rare, long-term)

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may exacerbate gastrointestinal side effects and potentially increase liver toxicity.
• Pregnancy - Etoposide is highly teratogenic and embryotoxic. It is contraindicated in pregnancy; effective contraception is essential for both male and female patients.
• Breastfeeding - Breastfeeding is contraindicated during etoposide therapy due to the potential for serious adverse effects in the infant.
• Liver - Use with caution in patients with hepatic impairment; dose adjustments may be necessary. Monitor liver function tests regularly.
• Kidney - Use with caution in patients with renal impairment; dose adjustments may be necessary. Monitor kidney function tests regularly.
• Lung - Rare cases of interstitial pneumonitis have been reported; monitor for new or worsening respiratory symptoms.

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