Fasvivo 250mg Injection

About

Fasvivo 250mg Injection contains Pemetrexed, an antifolate antineoplastic agent used in the treatment of various cancers, primarily non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma. Pemetrexed works by disrupting critical folate-dependent metabolic processes essential for cell replication. It inhibits several key enzymes involved in purine and pyrimidine synthesis, including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).

By interfering with these pathways, Pemetrexed effectively halts DNA synthesis and repair, leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. This targeted action makes it an effective chemotherapy agent, often used alone or in combination with other drugs, to improve survival and manage disease progression in eligible patients.

Uses

• First-line treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC).
• Maintenance treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC).
• Treatment of malignant pleural mesothelioma in combination with cisplatin.
• Treatment of recurrent non-small cell lung cancer after prior chemotherapy.

Directions For Use

Administered intravenously by a qualified healthcare professional. Dosage and frequency are determined by your doctor based on your condition and body surface area.

Benefits

• Effective against specific types of lung cancer and mesothelioma.
• Can be used as monotherapy or in combination regimens.
• Improves progression-free and overall survival in NSCLC.
• Approved for maintenance therapy in advanced NSCLC.
• Well-characterized safety profile with appropriate supportive care.
• Targets multiple folate-dependent enzymes crucial for cancer cell growth.

Side Effects

• Nausea
• Vomiting
• Fatigue
• Anorexia (loss of appetite)
• Stomatitis (mouth sores)
• Diarrhea
• Constipation
• Rash
• Hair loss (alopecia)
• Myelosuppression (low blood counts)
• Peripheral neuropathy
• Fever

Safety Measures

• Alcohol - Avoid alcohol during treatment as it may worsen side effects like nausea, fatigue, or potential liver toxicity.
• Pregnancy - Contraindicated in pregnancy due to potential for fetal harm. Women of childbearing potential should use effective contraception.
• Breastfeeding - Not recommended during breastfeeding due to potential harm to the infant. Discontinue breastfeeding during treatment.
• Liver - Use with caution in patients with mild to moderate hepatic impairment. Dose adjustment may be needed for severe impairment.
• Kidney - Dose adjustment is required for patients with moderate to severe renal impairment. Not recommended for severe renal impairment (creatinine clearance < 45 mL/min).
• Lung - Monitor for new or worsening pulmonary symptoms, including dyspnea or cough, as interstitial lung disease can occur, though it is rare.

Disclaimer

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