FLAGYL 400MG 15

About

Metronidazole, commonly known as Flagyl, is a synthetic nitroimidazole antimicrobial agent with potent activity against anaerobic bacteria and various protozoal parasites. Its mechanism involves intracellular reduction of its nitro group, forming reactive cytotoxic compounds that disrupt DNA synthesis and other vital cellular processes in susceptible microorganisms, ultimately leading to cell death. This makes it highly effective in treating a range of infections, including those caused by *Bacteroides*, *Clostridium*, *Helicobacter pylori*, and protozoa like *Entamoeba histolytica*, *Giardia lamblia*, and *Trichomonas vaginalis*. Metronidazole is a cornerstone in the management of anaerobic bacterial infections, amoebiasis, and trichomoniasis, often used in both therapeutic and prophylactic settings.

Uses

• Treatment of anaerobic bacterial infections.
• Management of amoebiasis.
• Therapy for giardiasis.
• Treatment of trichomoniasis.

Directions For Use

Take one tablet orally with food or milk to minimize stomach upset, usually 2-3 times daily, as directed by your doctor. Do not consume alcohol during treatment.

Benefits

• Highly effective against anaerobic bacteria.
• Potent antiprotozoal activity.
• Good tissue penetration, including CNS.
• Available in various formulations.
• Relatively well-tolerated for short courses.
• Key drug for *Clostridium difficile* infection.

Side Effects

• Nausea.
• Vomiting.
• Metallic taste in mouth.
• Diarrhea.
• Abdominal cramps.
• Headache.
• Dizziness.
• Darkening of urine.
• Peripheral neuropathy (with prolonged use).
• Seizures (rare).
• Candidiasis (thrush).
• Rash.

Safety Measures

• Alcohol - Strictly avoid alcohol during treatment and for at least 48-72 hours after the last dose due to severe disulfiram-like reaction (nausea, vomiting, flushing, headache).
• Pregnancy - Generally avoided in the first trimester; use in later trimesters only if clearly needed and benefits outweigh risks. Consult a physician.
• Breastfeeding - Not recommended during breastfeeding as it passes into breast milk. If essential, consider temporary cessation of breastfeeding.
• Liver - Use with caution in severe hepatic impairment; dosage reduction may be necessary due to impaired metabolism. Monitor liver function.
• Kidney - Use with caution in severe renal impairment; dosage adjustment may be needed, especially for extended-release formulations.
• Lung - No specific contraindications, but monitor for signs of pulmonary fibrosis in rare, prolonged cases.

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