FOEPHOS SACHET 1X1

About

Fosfomycin is a unique broad-spectrum bactericidal antibiotic primarily indicated for the treatment of uncomplicated urinary tract infections (UTIs) caused by susceptible Gram-positive and Gram-negative microorganisms. Its distinct mechanism of action involves inhibiting an early and essential step in bacterial cell wall synthesis. Specifically, fosfomycin irreversibly inactivates the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), which is critical for the formation of N-acetylmuramic acid, a precursor to peptidoglycan. This inhibition prevents the construction of the bacterial cell wall, leading to osmotic lysis and bacterial death. The drug's ability to achieve very high and sustained concentrations in the urine, coupled with its single-dose efficacy, makes it a highly convenient and effective therapeutic option for acute bacterial cystitis, offering a valuable alternative in an era of increasing antibiotic resistance.

Uses

• Treatment of uncomplicated urinary tract infections (UTIs).
• Effective against E. coli and Enterococcus faecalis.
• Used for acute bacterial cystitis.
• Often prescribed as a single-dose therapy.

Directions For Use

Dissolve the entire contents of the sachet in half a glass of cold water and drink immediately. Take on an empty stomach, preferably at bedtime after emptying the bladder.

Benefits

• Highly effective for uncomplicated UTIs.
• Convenient single-dose treatment.
• Achieves high concentrations in urine.
• Broad spectrum of activity against common uropathogens.
• Low incidence of resistance.
• Generally well-tolerated.

Side Effects

• Diarrhea
• Nausea
• Headache
• Dizziness
• Abdominal pain
• Dyspepsia
• Vaginitis
• Rash
• Fatigue
• Pruritus
• Paresthesia
• Asthenia

Safety Measures

• Alcohol - No specific interaction with alcohol is known, but it's generally advisable to avoid alcohol during antibiotic treatment.
• Pregnancy - Use only if clearly needed and potential benefits outweigh risks; consult a doctor.
• Breastfeeding - Fosfomycin is excreted in breast milk; caution is advised, and a doctor should be consulted.
• Liver - No specific dose adjustment is typically required for patients with hepatic impairment.
• Kidney - Use with caution in patients with severe renal impairment (creatinine clearance <10 mL/min); dose adjustment may be necessary.
• Lung - No specific precautions for lung conditions; general monitoring is advised.

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